Hormone Therapy - Relugolix Side Effects

Hi Dartmoor , I noticed nobody had replied so my reply will bump you back up the list.  These are all side effects but I think you would be very unlucky to have them all as a result of treatment although I guess not impossible.  I always immediately jump to the conclusion with any ache or pain that it is PCa related, but most of the time things are age related in my case.  Just make sure that your team and/or GP are aware of any symptoms. 

Most of us are at an age where stuff starts dropping off anyway, so there is a temptation to blame these unfortunate side effects of not dying on the cancer.

When you have Cancer it can be difficult to understand that you can have other problems as well.

We become so fixated on the cancer that all else pales into insignificance.

It's a thing to watch for.

Back problems are just as painful if they are not caused by Cancer, I can tell you.

Hello Dartmoor

I was similarly diagnosed with locally advanced PC in the summer of 2024, and started on Degarelix 4-weekly jabs in October 2024. I had my RT in March 2025.  Initially the jabs were OK , but the injection site reactions steadily got worse, and in the meantime Relugolix had been approved so I started on Relugolix tablets  in October 2025.  The side effects , are broadly similar with hot sweats, fatigue etc., but I also get a general brain fog, plus headache with occasional dizziness. Mostly it's OK, but some days it makes it almost impossible to achieve anything.  I just can't push through it.  My sleep is also worse than on the jabs. The other effect is the joint stiffness and pain. I'm (Or at least was prior to the start of the HT) fairly fit, and have been weight training twice a week to prevent muscle loss. Despite that, I really notice the stiffness when getting up of the floor, or doing akward DIY tasks in cupboards etc..  The insert with the pills does list this as very common, so I'm not surprised.  The other thing is my guts. WHen I started the Relugolix pills my guts became quite disturbed and unstable, swinging from constipation to running too fast and back again, but they have settled down now and although not normal (i don't hink they ever will be post RT) they're pretty good. On balance, I'm content to stay on the Relugolix pills until the end (October !) but I'l be glad when it's over. 
Best wishes

John. 

Hi Dartmoor,

My experience with Relugolix was 'as well as could be expected' for any HT treatment. It affects everyone differently, but my personal experience when I was on this treatment onlywas quite tolerable for the 3 years prescribed. Plus the big advantage of rapid testosterone return when we finish HT. Things are harder with RT and Abiraterone added to the mix but I am determined to push through it to get the best chance of a cure.. Please click on my name or avatar if you want more detail.

Stay strong and look to the prize at the end.

Regards

David