Metastatic prostate cancer

Hello Brunyer .

I am sorry to hear that the chemotherapy has stopped working but glad that you are being treated by a centre of excellence who have access to the best in treatment.

There are other treatments available but it depends on what you have already had and where the cancer is lurking. My husband has T4 prostate and has been through 3 recurrences so far in 4 years. My go to reference on what is available is this video - it is long so give yourself an hour.

https://youtu.be/-RVVq0uDAEE?si=V4848u1R9PnXqjFN

There is also an article on current developments which you might find interesting.

https://www.icr.ac.uk/news-features/latest-features/the-future-of-prostate-cancer-research-what-could-the-next-decade-bring

One area I am interested in is called Bipolar Androgen Therapy BAT which is looking at how to overcome the cancers resistance to hormone therapy after long term use and is currently at the stage III trial.

If you haven't already had genetic testing done then this might be helpful for determining what therapies might be suitable for you in the future.

Please come back with any questions.

Hi Brunyer  sorry to hear that both main chemos have stopped working.  I guess like me you have been treated for some while but without your history I am not sure.  Are you able to add a brief resume on your profile?  Best wishes, David

Hi I had 6 sessions of Docetaxel which seemed to work at first but two months later psa started rising , Had all the restaging scans and they decided to give me 10 sessions of Cabazataxel I am currently a week away from my tenth but it doesn’t seem to have sorted my psa the last scan I had 2. Months ago showed no progression but we will see I could be in the same boat as you 

In response to your particular query it has spread to the liver

There is a bit in the video which states that the attitude for treatment of liver mets has improved as the liver is the only organ which can regenerate after ablative treatment. I have found an article which suggests that Olaparib (a PARP inhibitor) along with microwave ablation was effective after standard treatments had failed but this was only offered after genetic testing had shown that they were suitable.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375954/

Another study suggests that SBRT could be suitable if the area of cancer in the liver is not too large.

I am not suitable for Olaparib. I had a liver biopsy to test my suitability