Treatment options

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Hello to all! I am 75 with newly diagnosed Myeloma after 4 years of smouldering monitoring. It is a lambda free chain myeloma. I am not transplant eligible as per my age. I was given options and thought the ISA VRd was the best although always concerned about the neuropathies associated. I read from GPT that the DRd was more appropriate for age and newly diagnosed condition and doses not have neuropathies. Has any one experience or knowledge of dealing with side aeffects and of the 2 treatment options above. Any comment will be greatly appreciated. Carlos