Hi,
I'm currently undergoing treatment for tonsil cancer - T2N1M0. Treatment plan is 6 weeks radiotherapy and 2 cycles of chemotherapy. Due to pre-existing mild tinnitus the chemo is Carboplatin at 5AUC weeks 1 and weeks 5. I'm currently at the start of week 5 of treatment.
About 3 days after the first chemo cycle I developed a spike in my tinnitus which has persisted for the last 28 days. Maybe about a 20% increase from baseline, making it much more intrusive. My single lymph node has resonded well to treatment so far, shrinking between 50-75%. I discussed with my oncologist and he said due to tinnitus and good response I could either omit the 2nd dose, or go for a reduced AUC 2.5 dose.
I arranged for the reduced dose for cycle 2, but then when I went yesterday (26th march) I got quite stressed about the possiblity of the tinnitus worsening and I didn't go through with the cycle. Now i'm a bit stressed about having missed that 2nd cycle - although I think the benefit of it is quite marginal. Maybe 6-8% for chemo overall, with most of that in the 1st dose. So maybe the benefit of the reduced 2nd dose might be 1-3%? I feel like i'm being a bit flippant with the cancer - but the tinnitus is quite impactful day to day and I really don't want it to get any worse than it is now.
Just wondered if anyone else missed the 2nd dose due to toxicity issues - or if people have experiences of tinnitus after chemo and whether it lasted or went away?
Thanks
Just wondered if anyone else missed the 2nd dose
Hi. Don’t stress. Lots of people miss that second dose.
I know Hazel missed one out of three. Percentage wise it makes very little difference whereas tinnitus is a major side effect to put up with.
Dani
Base of tongue cancer. T2N0M0 6 weeks Radiotherapy finished January 2019
Whatever cancer throws your way, we’re right there with you.
We’re here to provide physical, financial and emotional support.
© Macmillan Cancer Support 2026 © Macmillan Cancer Support, registered charity in England and Wales (261017), Scotland (SC039907) and the Isle of Man (604). Also operating in Northern Ireland. A company limited by guarantee, registered in England and Wales company number 2400969. Isle of Man company number 4694F. Registered office: 3rd Floor, Bronze Building, The Forge, 105 Sumner Street, London, SE1 9HZ. VAT no: 668265007