To all ladies on Letrozole.......

For anyone interested in the details, I found an article on "Oral vitamin B12 to improve aromatase inhibitors (AI)-associated musculoskeletal symptoms (AIMSS)." It is about sub-lingual B12 decreasing pain.

I have been taking for a few days and found it definitely improving energy levels as well.

"Conclusions: This study suggests that vitamin B12 reduces pain and improves quality of life for patients taking AIs who experienced AI-related musculoskeletal symptoms. If confirmed in large randomized prospective trials, Vitamin B12 would be a safe and cost effective option for the treatment of AI -related musculoskeletal symptoms."

The research is from "Journal of Clinical Oncology"   https://ascopubs.org/doi/abs/10.1200/JCO.2017.35.15_suppl.e21679

Cheers and love

I am writing to say ,I was given two weeks Glenmark and I think they are fine. I cannot find them on bnf so maybe old . Doctor has given me Teva for a month it's£76 . So I start tomorrow . Will let you know . Keep well. 

Just picked my 4th presciptjon and 4th different brand.  Has Crescent, Teva, Glenmark and just picked up Manx.  Haven't noticed any difference to be honest.   Hard to know if fatigue is still effects of operation and trying to heal.  Bought some B12 vitamins after reading an earlier post.  

Just picked up 4th prescription and 4th different brand!  I've had Crescent, Teva, Glenmark and just picked up Manx.  Haven't noticed any difference to be honest.  Not sure if fatigue is down to tablets or still effects from op and healing issues.   Just bought B12 vitamins after reading one of earlier posts.  Interestingly they were on the shelf marked fatigue - so hoping they may help.  Worth a try.

Hi AnnJac,

i asked for B12 in Boots today, they only had capsules so as it was a tiny branch shop I thought I’d wait till I got to a bigger shop....

hugs xxx

I went for the capsules Moomy.  The article didn't seem to distinguish?  Had to get some other B vitamins with them.  But got a high strength one which had 500Mu of B12.  The ordinary ones only had about 10Mu I think.  Tesco.  3 for the price of two so got 90 days supply.  Can't do any harm.  Whether there is a better one I don't know.  I was in Tesco picking up prescription anyway.  Be interested  to hear what you can get from Boots.

Hi AnnJac,

the article actually quoted sub-lingual I thought (liquid, drops under the tongue) which is what I’m going to try to get....

hugs xxx

I read it again and it did!  But the tablets may help.  Do let me know if you can get sub-lingual from boots.  If you can I'll pick some up next time I'm at big Boots - in the mean time I'll take these as it may help .....

Will do, AnnJac!

we are planning a bus ride to Poole tomorrow, where there is a decent sized Boots if I remember rightly. Will try there, as my ankle and foot pain has got a bit annoying recently! 

Hugs xxx

Yes, they tested the sublingual and that is what I am using; small tablets that dissolve under the tongue and go straight to the bloodstream.  Apparently they have drops too. 

The normal tablets or capsules of B12 have to be absorbed in the stomach and if this is not working too well, they don't get absorbed properly and just pass through the system ...

Sublingual works much faster.  If you are short of B12 you notice the difference within 15-20 minutes... I do. I take 1.2mg (1200mcg) twice a day and it helps.

Cheers