Dear friends
I’m on my way home from the hospital after picking up ct scan results.
The bad news is that the cancer has grown since the start of the immunotherapy in October. Boo. Mostly the tumours are still too small to cause me problems but they’ve grown enough to take me off the trial.
My doc did have something else to offer me. It’s another trial, this time of a drug that inhibits DNA repair. The theory is that this drug, combined with the brca mutation (which also inhibits DNA repair) might give the cancer a double whammy. It’s the same theory as the PARP inhibitor that I took back in 2016. Anyone with a science interest, it’s an ATR inhibitor known as AZD6738. It comes as a tablet. Not much is known about the side effects but they include the usual - nausea, fatigue, anaemia.
Here is a link https://www.cancerresearchuk.org/about-cancer/find-a-clinical-trial/a-trial-looking-AZD6738-radiotherapy-advanced-solid-tumours-patriot
They hope to start me on this either just before or just after Christmas.
Here I go again.....
Xxx
Aw
You're being shoved from pillar to post and all that is sapping the nervous energy out of you. No wonder you're tired, I'd say a good rest is called for, there's nothing more you can do. Sit back and kick off your shoes.
Yeah, the weather was foul today, I wouldn't recommend walking around in pyjamas in it lol.
I'm sending you a big hug because you need a big Tvman hug.
Goodnight, and sleep tight.
Tvman xx
Hi
I wish you the best of luck for the next four weeks, Lynn, I'll have my fingers crossed for you for 4 weeks.
Tvman xx
Hi ,
I think that we all crave certainty and struggle when we don't really have a clear direction of where we are heading. A good rest seems like a lovely idea, especially when the weather is so inclement. It was really windy up here yesterday but this morning looks surprisingly good. It is supposed to be dry with some sunshine but apparently once I venture through my door it will be very cold.
I know that you have confidence in your team so hopefully they will soon have you moving forward with a plan again. Until then enjoy the break.
love and hugs,
Gragon xx
before I got on my immunotherapy trial it was a bit hot and cold like that, sending me into the gloom’s......with hindsight, they were havering because of it being tricky to get a biopsy and they couldn’t go ahead without one. The consultant said we will never put you at risk just to get you on a trial, so you might find it is that. They wouldn’t go near my liver for example, which was where my biggest tumour was.
fingers crossed it’s that and they will have a better idea when they have had a good look at the scans (and mine needed a second opinion before they went ahead) xxxxx
Hi Daloni
Wishing you well and hoping things go forward for you xx
Thanks for the boost. You’re right , there is always a certain amount of arsing about with trials and safety has to be the top priority. I’m actually quite good at living with uncertainty as a rule. It was just that I’d used the device of looking forward to something hopeful rather than backwards at something I can’t change as a device for not getting bogged down by the crappy scan results.
I have had a lovely morning that’s brought in a dog walk, a nap and some crochet followed by a cheese toasty and equilibrium has been restored
xx
Oh Daloni
I'm so sorry to read you had to come off the treatment
Your team sounds like they r on the ball
I wish u all the best on the new trail treatment I will b praying 4 u this one is ok
Lots of love
Kym xx
Dear daloni,
I’m thinking of you during all the changes. Again who knows -give a run if you are up to it. You never know. We are not in control all by ourselves - and it seems you have had good luck in extending your time from on High.
I really like the name cheesy toasty. Sounds great. Wish I could come over and taste one with you.
I think I owe you a virtual tour of Kauai to warm you up. I’ll start working on it when I return.
In the meantime try to disconnect from it try to Enjoy the day while waiting
I just found Justice Ruth Bader Ginsberg’s exercise book routine all in house with bands she has beat serious cancers 3 times by keeping strong Focuses the mind I’m going to start her PT routine tomorrow- supposed to increase muscle and strength and posture. So I’m going to try it.
Anyway do what ever is good for you and yours. Please don’t let the medical procedures run you down. Wish I could help in some way.
Rest, love, music and dream.
Hugs to you and yours.
Millie
Thank you, Millie . You are quite right that exercise really does help, especially if it’s outdoors. The dog is getting me out and about and it’s been so therapeutic. I can let her off the leash now so she can run round while I stagger along slowly with my walking stick.
I shall think of you while eating cheese today. I have two dear friends here this weekend so it’s all go. We have just booked tickets for the Pre Rephaelite Sisters exhibition at the National Portrait Gallery in London. It’s a beautiful gallery, right on Trafalgar Square, and I love the Pre Raphaelites. My mother was fond of telling me I looked like Elizabeth Siddal.
You have a great day
xxx
Hi Millie
Hope you are well and not too unhappy about having to stay in Kauai (love to know how to pronounce it btw, maybe you can help us with phonetics). If you were able to put up a virtual tour, the site might crash because I'm sure there would be more than Daloni and I looking at it!
You haven't lived if you haven't had a cheese toasty although I must say I more than likely would have ham in mine too but my favourite would be a French version, a ham and cheese toasty with a fried egg on top, called a Croque Madame. Without the egg, it's a Croque Monsieur. I am a Francophile at heart. I have a recipe book that has various different combinations of foodstuffs in between the slices of bread.
Good luck with the routine, hope it keeps your body young and supple
Tvman xx
Whatever cancer throws your way, we’re right there with you.
We’re here to provide physical, financial and emotional support.
© Macmillan Cancer Support 2025 © Macmillan Cancer Support, registered charity in England and Wales (261017), Scotland (SC039907) and the Isle of Man (604). Also operating in Northern Ireland. A company limited by guarantee, registered in England and Wales company number 2400969. Isle of Man company number 4694F. Registered office: 3rd Floor, Bronze Building, The Forge, 105 Sumner Street, London, SE1 9HZ. VAT no: 668265007