I will continue with my search for this topic, but my question might be quite specific and I may not find any hits.
I'm really struggling with the hot flashes while on ADT (Zoladex). At first I found it funny and even joked with my wife (menopausal) about lining up the events so we could effectively manage the thermostat and bed covers.
I no longer find it funny. It wakes me up anywhere from 15 to 25 times every night (according to my smart ring and the dark circles around my eyes). I'm trying to get my radio-oncologist to put me on a clinical trial for Veozah (Fezolinetant) but no luck so far. The "small dose antidepressant" approach doesn't appeal to me and apparently has barely moderate success.
But my wife's endocrinologist recommended that I look into Genesta's Estrovera (used very successfully with menopausal women, it's a highly selective agonist of estrogen receptor beta (ERβ) and is considered highly safe *and* effective for women). There have not been any clinical trials for men on ADT, but the ERβ agonism in the prostate is actually considered potentially favorable, not harmful. Still, no clinical trial means not well understood.
So here I am with a few questions.
- Anybody else *really* struggling with hot flashes?
- Any solutions, workarounds, tips or tricks?
- Any direct knowledge or experience with Estrovera?
- ... or Veozah?
I feel like a whiner for lamenting so much about "just" hot flashes, but they are really having a detrimental effect on my sleep and therefore quality of life. I've been on Zoladex since November, and am not sure I can put up with it for 7 more months
Any advice or encouragement appreciated
