PSA - big drop and then a sudden rise.

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Hi Guys, new here.

In summary my situation is:

Radical Prostatectomy 13 November 2019 then PSA as follows

21 Jan 2020 = 0.04 

20 April 2020 = 0.04 

24 July 2020 = 0.04 

10 November 2020 = 0.08 

15 December 2020 = 0.05 

16 March.2021 = 0.08 

15 June 2021 = 0.14 

22 June 2021 = 0.13 

15 September 2021 = 0.17 

10 December 2021 = 0.28 

17 March 2022 = 0.27 

9 June 2022 = 0.31 

06 September 2022 - 0.41 

22 December 2022 – 0.42 

Finished Salvage radiotherapy mid January 2023

11 March 2023 – 0.27 

2 June 2023 – 0.18 

13 September 2023 - 0.13 

14 December 2023 <0.03 

13 March 2024 0.11 

I was surprised to have the 0.1 drop in December, and nearly as surprised to see a 0.8 rise this month. Can anyone offer an explanation please?

  • Just a quick thought PCV

    December a blip, but it is still going down IE. .27 to .11

    Wait for the next one, looks ok

    Best wishes

    Steve

  • Hello  A warm welcome to the Community.

    I don't think you have anything to worry about.  Overall your PSA readings are pretty constant and the differences in readings are "marginal". There could be many reasons - exercise in the previous 48 hours, the testing laboratory could be different for one or two tests, even infection of the area where the Prostate was. 

    You look to be doing fine by me - but I am by no means a professional.

    Best wishes - Brian.

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  • Thanks chaps. Looking at it from a data perspective, it doesn't make a lot of sense. But there is something about PCa that has a habit of kicking you, just when you think you've dealt with it. I think I am permanently looking for that.

  • It's something - once you have it - it's there at the back of your mind all the time.

    You cut your finger - you see the cut - you wash it - put a plaster on it - a week later - it's fine, you take the plaster off and you are good to go.

    Cancer - you can't see it - you have to be in the hands of others to tell you how you are doing - and that's the big difference.

    You are doing fine though - all looks good to me.

    Best wishes - Brian.

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  • Part of the difficulty for me has been lack of medical consensus. On more than one occasion I have been told that I am incurable, whilst other medics have contradicted it and said that I was curable or that PCa won't kill me. It doesn't make forward planning very easy!

    My original tumour was T3a Gleason 8. and I had a RP at age 54. I needed salvage RT at 56 due to some cancer in the prostate bed. So I am quite young in PCa terms and have a number of years in which I want to stay ahead of the disease.

    I am given to understand that if it recurs in the prostate bed it is nowadays possible to revisit the situation with RT, furthermore that distant mets can be treated quite often.

    But assuming it comes back somewhere where it cannot be treated, how long can other treatments prolong things?

  • Ah - I fully understand where you are with that one.  I am a T3a - Told it "might" have spread - than it's not - yes - make your mind up,

    Yes, I agree - you can have RT to the prostate bed - there are also many new treatments now either available (Triplet Therapy etc) or coming online so I am sure things will be fine for you - easy for me to say I know - but stick with it.

    The Community is always here for you - ask anything - you will get answers.

    Best wishes - Brian.

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