Enzulatamide for castrate resistant cancer

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Hi, does anyone here have experience of enzulatamide therapy after hormone therapy on its own has stopped working? That is after the end of remission. 

I had RP in Dec 2018 and in Dec 2019 I was diagnosed with lung only metastatic prostate cancer. I underwent 4 months of chemo and hormone therapy. 

But the hormone therapy (ADT) does not work indefinitely. When that happens I will most likely be prescribed enzulatamide since I could not tolerate the steroids that have to be taken with abitaterone. 

So, what is enzulatamide like? How fatigued are you? How has it affected your quality of life? 

Patrick

  • I'm not on it, but I talk with many men on it. It comes with a worryingly long list of side effects, but they are just the regular hormone therapy side effects and you probably already have those you're going to get, so usually nothing extra appears. Some men think it does make their fatigue a bit worse though.

    All men on hormone therapy should consider exercise as mandatory if they are physically able, and exercise is the best antidote for hormone therapy fatigue (regardless of taking Enzalutamide or not).

  • Hi Andy thanks a lot for that. I agree with you about exercise. It’s one of the few effective interventions for some of the side effects of ADT.

  • Hi Andy

    I’m on enzalutamide have been for a few years, done chemo etc so this was the next step. I’m on metfirmin ( diabetes) started it same time as enzalutamide four sets of both tablets hit my brain for six, cut metformin down to 2, also enzalutamide to 2 and built up to 4 enzalutamide over 4/5 weeks, they do make you tired and fatigued, with the odd where did I put that thrown in, but Arbiraterone needs a steroid, not for me, tried prednisone went 8/7/6/5 to 1 didn’t notice a change.

    I rely on my team to give me the best information, they see me every three months, have done since being diagnosed in 2016, I have mets in ribs, spine and pelvis maybe shoulders that I know of, a devil some days but better than the alternative.

    stay safe

    Joe

  • I've been on hormone injections and enzalutamide for nearly 2 years, yes it causes fatigue but it never really effected my quality of life, I  still go to work part time and enjoy a good social life, in fact the oncologist has suggested I go down to 3 tablets instead of 4 to improve my quality of life. But everyone is different to the response of the treatment, I agree with doing exercise and just trying to be positive.