I´m writing from Spain where I realise medical procedures and protocols may well be different from in the UK. Briefly, 18 months ago after my PSA had risen to 9.6 but DRE was normal I had a TRUS biopsy, which was negative but with one core showing ASAP. Six months later my PSA dropped to 8.5, then six later to 7.4. However, after the last PSA result, I was sent for an MRI scan. The results, which I got in June showed a lesion in left lobe, rated as PIRAD 4 - likely to be a malignant tumour. I was then told I needed a targeted biopsy. The consultant was a bit perplexed as my PSA was gong down and my DRE continues to be normal. Unfortunately, the wait for the biopsy is neverending, looks like it won’t be till beginning of October. At this point the wait is almost the worst thing. However much I try to prepare myself for the worst there is a little bit of me wanting to think they might be mistaken. I have looked at academic papers on the net but just wondered if anyone knew of a case where despite PIRAD 4 or 5, the biopsy was negative. Many thanks in advance
Hi Peter
you are probably aware that PIRAD is an enhanced MRi that gives a score similar to a Gleeson score in a biopsy. ie 4/5 is highest with malignancy likely(PIRAD that is).
You still need the biopsy to confirm, obviously this is what u are waiting for.
couple of strange things though, psa going down not up and previous biopsy negative. Did u have a MRi before the first biopsy or were they going in blind with the Trus biopsy?
At this stage obviously impossible to say that its def a malignant tumour, only the biopsy will say for certain.
I know that its the waiting that does your head in but even if it does turn out be malignant , looks like its contained and therefore easily treatable. By the way what is ASAP in one core?
regards
Steve
Many thanks for your swift reply, Steve. The TRUS biposy was blind and ASAP is atypical tissue, it's an English acronym, I though core was the name they gave to each sample they take … I omitted also to mention my age - 59 at the moment. As you say, it is the waiting that's driving me crazy, especially as I was originally told it would be six weeks and it's now 3.5 months.
do u know why u are having to wait so long? can u not try and push it forward, perhaps they view as non urgent because of size and proximity, do u know the size of the tumour by the way?
If you were to say that its 3 or 4mm in size and we know that the psa going down , time is probably on your side.
Steve
I think the wait is due to an accumulation of patients and summer, etc. As I say the system here is different, my form said “preferente” which is second, between “normal” and “urgente”. I went to patient services at the local hospital where biopsy is to be performed and put in a complaint form yesterday, which apparently might get me shifted forward or shipped out to another hospital. Not sure of the size of what they refer to as a “lesion” but the consultant didn’t seem unduly concerned. I do know there is only one, however.
Ok, so hopefully small lesion, at worst. I think that you can relax a bit, yes I know, easier said, have a good weekend
Steve
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