Lutetium 177

My husband was diagnosed with Advanced Metastatic Prostate Cancer in November 2024 with PSA of 311.

He completed triplet therapy and PSA came down to 4.6 but within about 3 months it started to rise again. He Darolutamide was stopped as his cancer had become hormone resistant and started a 2nd course of chemo which was stopped in Feb as it wasn't working and PSA was still rising.

He is now under The Royal Marsden waiting for a slot to become available on a clinical trial.

We too have looked at Lutetium-177 and his PET scan shows his cancer has the protein PSMA.  However, we would have to self fund this treatment and from the research I have done to date it would prolong life by about 4 months so it is a big decision to make.

I too would like to hear about others experience of this treatment.

Thanks so much. Our oncologist has said she’s seen good sustained responses with Lutetium 177 when used at a slightly early stage (I think the clinical trials where the 4 month data was when it was used as a last resort treatment). I appreciate it’s a massive decision whether to self fund though, so send lots of support. If you’re speaking to the Royal Marsden, it’s worth asking about the new immunotherapy drug VIR-5500 as that seems to have had remarkable success. Please do DM me if you’d like to share info / experiences. All the best, Anna

Hello Anna (Anna42) 

I ran your question about members who had had this treatment with our search facility and the beat answer I got was this:

 Prostate cancer lutetium 177 treatment 

The member posting it isn't an active member but the links still work.

Best wishes - Brian.