Psa rise?

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Hi my mame is Jovan 77year.Diagnosis:2022y Gleason score 3+4 (ISUP Grade Group 2), clinical stage T2b
Pre-radiotherapy PSA: ~8.8 ng/mL
1 hormonal injection (androgen deprivation therapy) before radiotherapy
Chart with upwards trend PSA course after radiotherapy:finish 24.4.2023
2 years after radiotherapy: PSA = 0.2 ng/mL
3 years after radiotherapy: PSA = 0.38 ng/mL
PSA doubling time (PSADT): ~10–12 months

What can be expected next?

  • Hi Boki02/Jovan,

    Sorry to see you here, but you are in the right place to get tons of information.  I am replying to keep your post at the top of the new posts.  

    I am also facing more treatment after my PSA has gradually risen to above 0.2.  My next step is another PET CT Scan on 22/05/26.  The likely next step depends on if they find a tumour.  I do know the likely treatment, if they find nothing, is hormones and radiotherapy.  As you are in a slightly different place, that may be different for you - hopefully someone else will reply with a better informed answer.

    We are all here cheering you on!

  • Hello Jovan ( 

    A warm welcome to the online Community although I am sorry to find you joining us.

    I am making a couple of assumptions here, do I assume you are outside the UK and you have been on yearly PSA tests?

    The normal procedure in the UK is for a clinical review after 3 rises or a rise of +2 whole points. Whilst I agree you have a doubling time of 1 year I think you will need at least 1 more PSA test before any further treatment reviews are made.

    I hope that helps.

    Best wishes - Brian.

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  • Psa every 3 months 4 rise psadt 10-11 months 0.2,0.25,0.31,0 38

  • Hello Jovan ( 

    I think with the PSA rises being "small" but a trend your team will be considering if it's a biochemical recurrence or PSA "bounce" after Radiotherapy. 

    if the rises continue the best course of action would be a PSMA-PET scan to see where the cancer is.

    Best wishes - Brian.

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  • Poslednji psa 0.336

  • In May 2026, the PSA was 0.38.

    In October 2026, the PSA decreased to 0.336.

    What does this mean after four consecutive PSA rises?

  • PSA measured every 3 months, with four consecutive rises. PSADT is 10–11 months: 0.20, 0.25, 0.31, 0.38.(may 2026 0.38)

    The last is 0.336 october 2026

    What next? 

  • Hello Jovan ( 

    I would consider that result of 0.336 to be great - it's not an increase and it's still a very low figure.

    I would relax and enjoy life and not to worry - let's see what the next test brings.

    Best wishes - Brian.

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  • PSA 0.336 was measured at a different laboratory. All the other PSA results were measured at the same laboratory, and the latest result  29.10 of 0.24  psa was also measured at the same laboratory as the previous test.”

  • Hi last psa 29.10 is 0.24