We had our oncology appointment today to go over Paul’s latest scan results and discuss what comes next.
The positive news is that there’s no evidence of progression, and the bone scan has shown significant improvement. The suspected new lesion has also been ruled out, which is a huge relief.
However, Paul’s PSA is continuing to rise, which suggests that something is happening somewhere, even if it’s not yet visible on scans. Because of this, the oncologist feels he may be becoming castrate resistant. Not the news we were hoping for, especially when we are only 8 months into this journey.
The plan for now is to continue with Abiraterone for the next 3 months, with further scans scheduled for the end of May. If those scans show progression, the next step will likely be a new treatment combination as part of the TALAPRO-3 approach (Enzalutamide + Talazoparib), which has shown promising results in men with a similar diagnosis to Paul.
Chemotherapy is still being kept as an option for later.
The oncologist also really emphasised how important it is for Paul to stay as fit and healthy as possible, as future treatments may be more demanding.
So, while this isn’t the update we’d hoped for, we do have a clear plan moving forward.
Next chapter begins… one step at a time. 
Hello Polly1912
Thank you for the update, there are plenty of positives there and it looks like you have a cracking team looking after Paul.
It's good to know you have a plan moving forward, and there are still "tools in the toolbox" should they be needed later.
However, Paul’s PSA is continuing to rise, which suggests that something is happening somewhere,
Now that's what is happening with me - PSA up but we can't find the little sods on a scan. My team are trying me on "intermittent Hormone Therapy" -it's just confusing when your PSA rises but you can't find the buggers!
I wish you both well moving forward, stay strong and keeping fit should enable Paul to take on the side effects. I think NICE only approved Talazoparib this January.
Do keep us posted.
Best wishes - Brian.
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happening to me...I will find out next Thursday all scans done 
am I am getting confused 
o couple of weeks ago I read a article saying immunotherapy doesn't work for pc,pancreatic cancer,and certain types of breast cancer. A week later i read a article on a local BBC site saying first man in the UK to undertake clinical trial of a very promising immunotherapy drug?
Hello Big Col
You are right to say immunotherapy isn't usual in the Prostate Cancer toolbox BUT research is going on and there are clinical trials:
Cancer Research UK - Clinical Trials.
Why not ask on Thursday if there are any suitable open clinical trials you can join?
Here's some more reading material:
Immunotherapy for Prostate Cancer - Prostate Cancer UK.
I hope the above helps - do let us know how you get on on Thursday.
Best wishes - Brian.
Macmillan Support Line - 0808 808 00 00, 7 days a week between 8am-8pm
Strength, Courage, Faith, Hope, Defiance, VICTORY.
I am a Macmillan volunteer.
Hello Steve (Grundo)
The testing you have read about is here;
Institute of Cancer Research - Immunotherapy.
I wasn't going to link this research as from reading the article last month I think it's a long way to go and the trial samples are very small to be approved by NICE.
Best wishes - Brian.
Macmillan Support Line - 0808 808 00 00, 7 days a week between 8am-8pm
Strength, Courage, Faith, Hope, Defiance, VICTORY.
I am a Macmillan volunteer.
I didn't know I could apply yet.I will. Hopefully on Thursday...Best case scenario little spread other than pelvic lymph nodes. Keep up your endeavours.
for the pc armoury. Thanks 
Hi polly it's a journey isn't it.Keep positive 
my fatigue from hormone therapy is bad and it's taken some effort but exercise has helped nothing excessive simple weights 10 mind twice a week...I still cycle and walk around the park.
