Degarelix Injections ~ Side Effects?

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Diagnosed in Nov '24 with stage 4, so I've been on a regime of Degarelix 80mg injections every 4 weeks.

I also take 2 X Abiraterone 500mg tablets daily.

To date I've had about 16 injections -- for the first 8 I had no side effects/reaction except for the 'usual' lump at the injection site.

However, on about 4 occasions I've had quite a nasty reaction -- around 7 or 8 hours after the injection I began feeling like I had a bad dose of flu -- shivering, shaking, unable to get warm and feeling extremely weak.  After a night in bed I was pretty much back to normal the next day but on this occasion the reaction set in early and was by far the worst it has been.  I spent day 2 in bed and today (day 3) I'm up and dressed but still feel very weak.  The injection site has a swelling of 3 inches in diameter and is bright red.  Previously there has sometimes been a little hint of redness for a day or two but nothing like this.

So, I guess there are plenty men on here who are having the same treatment -- do any of you have a reaction anything like this?

  • Hi  I am on stomach 12 weekly Zoladex so not any direct advice.  Think I would give 111 a call and just get a professional view.  Hopefully you will get other bits of advice from guys on Degarelix.  Let us know how you get on so others will know.

    Best wishes, David

    Please remember that I am not medically trained and the above are my personal views.