Degarelix Injections ~ Side Effects?

Hi BAKsteel I am on stomach 12 weekly Zoladex so not any direct advice.  Think I would give 111 a call and just get a professional view.  Hopefully you will get other bits of advice from guys on Degarelix.  Let us know how you get on so others will know.

Hi, BAKsteel,

Sorry to hear that - sounds pretty bad. I am not on that injection, but my understanding is that the direct equivalent is Orgovyx daily tablet, which is what I am on. Might be worth trying to switch to that with such a bad local reaction.

I start my abiraterone (/predisolone) tomorrow. How have you found that for SEs incremental to HT? My pharmacist said that this can affect your immune system, making one more susceptible to colds and flu. Have you found that to be the case?

Thanks

David

Hi DavidEB ~ I've been on Abiraterone + 5mg Prednisolone for 13 months now.  I was advised that the tablets combined with the injections could cause (among other things) hot flushes and I've certainly had my share of these.   Although not painful, they're extremely uncomfortable and I had a lengthy spell when I was having 9 or 10 in a day and lasting 4 - 5 minutes at a time.

As for colds and flu, I've not been visited by either although for most of the winter I have an almost constant runny nose.

Thanks,

Interesting.... It's hard o know, I guess whether the hot flushes are primarily from the HT or the AbiPred?

Mine are almost non-existent on Orgovyx HT. ("we're all different") I guess I am about to find out the delta effect some time after I start tomorrow! I will let others know when the time comes (or not, hopefully ;-)

Anyway, spring has sprung in Kent today..

All the best

 David

I was on Degaralix for over 12 months before switching to Relugolix once my local hospital trust had approved it. I occasionally had similar symptoms too what you described but only mildly however everyone one of them caused swelling/redness and pain at the injection site which lasted approx 7 days and was awful 

Hello, my partner is on the same medications as you. He hasn't experienced the flu like symptoms that you describe but he sometimes has a reaction at injection site, sometimes redness that goes the way round to his back....this is mostly down to poor technique, I am a nurse and come across this at times. Whenever someone new administers Paul's injection he always explains that the medication needs to be mixed well and administered slowly, he rarely has any issues now with redness. Not all nurses will be familiar with that type of injection and its ok to say something. However, saying that, you should flag any discomfort to your team so they can advise. 

Wishing you all the best

I have to disagree it's not down to poor technique, my regular nurse knew exactly how to reconstitute it and always took 30 seconds to inject it and so did the two nurses who gave me the first injections on the urology ward. My oncologist said it's simply a side effect of the drug, hence why he recommends patients have Triptorelin as you don't get the redness and pain at the injection site that you regularly get with Degaralix 

Hi Polly and Sprinter   ~ That last injection on Monday was administered by a nurse who doesn't normally do my injections (although it was she who did my first 2 or 3 back at the beginning in Nov '24).
In any case, I contacted my Oncology nurse at the hospital and explained what has been happening. She DID suggest that the way in which it is administered CAN sometimes lead a to nasty reaction. However, she has consulted with my doctor at the hospital and called me back today and he has discontinued the Degarelix and from next month I will be on an oral, daily drug. (She did say its name but my brain didn't grab hold of it -- I'll find out when I pick up my prescription.)

Hey ho . . . no more flu-like symptoms or painful swellings on my belly

It will likely be Relugolix (Orgovyx), I'm not aware of any other oral replacement for the hormone injections