Radium 223

My partner is 69, diagnosed in July 2023  ~ Gleason 4 + 5: T3b: M1 with a PSA 30. Bone scan revealed multiple abnormalities involving the 6th rib, right iliac crest acetabulum and ischium together with the right femoral neck.

Originally on monthly Degarelix injections and recently changed to Prostap 3 monthly injection and daily apalutamide.  Had a course of 6 weekly radiotherapy in December 2024.   

Was on Apalutimide for 14 months before it stopped working and went on the watchful wait for 10 months whilst the Cancer spread to more bones and the PSA levels started to creep up therefore 10 rounds of 3 weekly chemo was planned which started in November 2025.  This was stopped after 4 rounds last week as it was not working and PSA has raisen to 136 and a decision was made to try radium 223.  My partner is now currently waiting for the referral to start this line of treatment.   We’re trying to steer away from Dr Google and ask on here for real life true experiences.  What we’ve been told so far is that this new line of treatment will only help the bones.   Once my partner starts on radium 223

• will the disease quickly spread elsewhere
• will he feel better than he did on chemo
• now the treatment for chemo has stopped will the spread of the disease speed up

Thank you in anticipation for your response.