Aggressive Prostate Cancer - Gleason 8 - Spread to LN, Bone and Pelvi

I think the following explains it.

It’s not the end of the road.

I think it’s hard to explain away what you’ve listed from the letter without some background of how you got to here.

Have you had a previous assessment with a Gleeson Score and a TNM staging.

These would allow us to have some idea of what is present and what this new letter means on top of the initial diagnosis.

There is a profile page where you can mention these scores and treatments in more detail at the top of this page when you press the green round button.

I know we can help you but a little more info might be needed.

Never give up, add your questions here and support will soon be on the way.

Many thanks for getting back to me. Yes, I saw this on cancer research, but reading this I am concerned that there is no hope for my husband and just wondered if anyone knows of any therapy coming up in the near future. 

Hello Journeyone 

I don't think "this is the end of the road".

Last time you posted any figures was in November 2023. At that point your husband was a Gleason 8 with a PSA of 0.2 after both Radiotherapy and Chemotherapy So do you have any up to date figures?

Here are a few of my thoughts:

* I assume the Chemotherapy was Docetaxel. There is also Cabazitaxel - has this one been tried?

* Whilst becoming resistant to PARP inhibitors I assume that he's been tried on Olaparb?

* Has he been tried on either Abiraterone or Enzalutamide yet? Whilst you can be resistant to one type of treatment - quite often others will work for you.

* There is a treatment called Radium 223 - this is used quite often when other treatments have failed.

* Have you asked your Consultant if he's suitable for any clinical trials being run at present. Link here - Cancer/research-clinical-trials.

Personally I think you need an appointment with your Oncologist - a face to face appointment where you can clear the air and find out just where your husband is with his treatment.

I hope the above helps - please do come back to me with any questions, although please remember I am not medically trained - just a volunteer with a few resources.

Best wishes - Brian.

Many thanks Brian. The below is the latest - September 2025.

Diagnosis :  Gleason 3 + 5 +8 adenocarcinoma of the prostate 7/20 cores. MCL 7mm, 70% of Core.

Presenting PSA 7.39 now 9.73

MRI T3a NO

Active Surveillance for 2 years 

PET/CT scan Metastatic prostate cancer, bone, pelvic and para aortic 

Summary. HT lifelong. Completed radiotherapy June 2023. The rest I have completed on the forum. His PSA is less than 0.01 which is stable.

Hello Journeyone 

So my understanding then is that apart from hormone therapy they are looking after him doing regular PSA tests and his PSA at the moment is 0.01.

If so that's great and the HT he's on now is doing it's job keeping the testosterone down and stopping the cancer from growing.

Best wishes - Brian.

Many thanks Brian. I like to think so. My husband is extremely positive and I think that is great (it’s me, that isn’t) however, I think I just panicked seeing that letter today and it frightened me, but I feel so much better now having shared this with you and the forum. You are all inspirational and caring people. 

Many thanks Lynne