6 months into my ADT, sharing my feedback

Hello everyone.

Hope everyone is doing fine. I wanted to share my inputs on my ADT and also seek some answers.

So I started my ADT back in Oct 2024, and am on same treatment since then. Its abiraterone, plus relugolox, plus prednisone.

So the good news of that PSA is undetectable, less than 0.06, and is consistently same.

But this treatment comes with its side effects. Firstly, the hot flushes are severe and happen any time all of a sudden. Second as we know is fatigue and tiredness. Particulalry after 4. To 5 pm evening, it looks like ur without any energy.

I am monitoring my liver enzymes, my lipids, bone density, and heart. My heart so far is ok as per the ECG and echo tests. However, lipid profile is elevated and thats coz of abiraterone.

Also till now my HbA1c was in pre diabetic range but now its diabetic range. Last value on 5th april is 6.7.

So my onco has aksed me to meet my endocrinologist and see whether i need to start on metformin.

Reg lipids, with triglycerodes and total cholesterol inc and on higher side, its still a wait and watch before i change my meds. Currently i do take atovastatin at 10 mg. So guess a change in the statin or its dose is coming up soon.

Now coming to my bone scans. This is real concern. My BMD has decreased at all places, spine, femur neck etc.

I am now borderline osteoporetic. Here, the villain is again abiraterone and the steroid predisone. Cant stop either as they are doing their job.

So I have started strength training in gym under the guidance of trainer. Calcium supp are on going in tablet form.

I met a orthopedic and after going throigh history and meds, he says its time for denosumab or teraparatide treatment to slow down bone loss.

I want to ask people in similar situations, what strategy is adopted? Anyone has exp of side effects of denosumab. My ortho says he prefere the teraparatide treatmemt over denosumab as it has higher efficacy.

Are there people who have tried either denosumab pr teraparatide, or a combination of both? What habe the results been and what were the side effects.

Reg denosumab i have heard many horror stories of atypical femur fractures, loss of the bmd gains after stopping it, and many side effects like eczema, bone pain, jpint pain etc

On youtube i saw vids in favor of teraparqtide over densosumab.

Anyone here who benefited from strength exercises and doing weight training?

Bye all and take care.god bless you all.