Surgery or Radiotherapy? Decision made!

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Decision made.  I’m pT3a, N0 M0 (see my profile for details ).  My extensive research points to a combo treatment of HT / RT / Brachy (NHS and NICE approved).  MDT met again a couple of days ago and their recommendation (without my input) was the same.  I had a consultation at Addenbrookes yesterday with a top prostatectomy surgeon and he agreed with me that my decision was the best one, as surgery would carry at least a 30% chance of recurrence.  So I collected my prescription on way out!   I took my first bicalutamide tablet taken this morning…..so the treatment is underway. Just over 62 days (NHS target) since GP referral so well done to them after a thorough diagnosis.  I feel like a weight has been lifted from my shoulders with regards to timelines (chasing the NHS, politely!), but I’m under no illusion that the next few months of treatment will present challenges.  My wife and I are a strong team and we intend to take everything in our stride and, hopefully, this curative pathway will prevail.  Here we go…..wish us luck! 

  • Hi AW,

    It's interesting that you haven't had any fatigue issues whilst on HT, & something just clicked in my brain regarding that.  I seem to recall that athletes & other sports people used to train at high altitude before major events as a way of improving their stamina (they may well still do this).  Something to do with the lower oxygen levels at altitude I believe.  Putting 2 & 2 together to make 5, I'm making a guess that your hiking trips in the mountains have actually been a real benefit in keeping fatigue at bay. 

    Maybe we should all be heading to the hills? Mountain

     

  • It’s exactly 2 years since my first PSA test - taken quite by chance when I visited the GP on a completely unrelated matter. A newly qualify locum noticed that I hadn’t had a PSA test since a “well man” check 8 years previously!  Unbelievably, the first words my usual (friendly) GP said to me when he had to refer me for further tests was “what were you thinking?  You have no symptoms, it’s probably nothing!”……,,,,,my PSA had risen from 2.6 at age 58 to 11.0 at age 66. I can still remember the feeling of panic when the word “cancer” was spoken and I entered the whirlwind of MRI, biopsy, CT, Bone scan etc.  I am in a very different place now.  Undetectable PSA and feeling optimistic for the future after RT & HT (brachytherapy boost).   However, I am not complacent- but I feel that I’m safer than the untested man in the street.     AW

  • It’s also been 6 months since my last HT jab.  I’m still having hot flushes (completely manageable), but apart from that I feel pretty normal.  Just back from two weeks hiking in the Italian Alps, with 1,000m ascents & descents, so no fatigue.  I expected a long time until the effects of HT to wear off, but as I have no libido I’m content to wait. Still maintaining the “use it or lose it” mentality and no ED once things kick off in the bedroom.  What’s next?  Austria for two weeks hiking, and continue enjoying life.  The rest - hopefully- should return in time. 

  • OK, so if you have been following my story so far, you know that I am currently waiting for “Tommy T” to return.  Despite the near miraculous return of testosterone for  in a relatively short period of time , I think I can relax a bit if I am going to fall within the “typical” timeframe:

    Interesting extract from The ASCENDE-RT study (mentioned in my bio) which also looked the cessation of hot flashes, and testosterone recovery after 12 months of ADT.  
    Hot flashes: 
    The median age of the men was 68 and hot flashes were reported in 93% of them.  These began at a median time of 4 months from the first ADT jab (with testosterone levels at castrate level).  The median time to cessation of flashes was 8 months after the cessation of ADT (last jab + 3 months, so 11 months after the final jab).  A resolution of flashes was reported in 99% of men.  
    Testosterone:
    The median baseline testosterone before ADT was 13.2 nmol/l.   The median times of testosterone recovery were:
    5  nmol :  8 months (96% of men).  So 11 months after final jab.
    7.5 nmol : 13 months (94% of men).  So 16 months after final jab.
    10 nmol : 18 months (91% of men).  So 21 months after final jab.
    Hmmm, I had 18 months ADT…. so if I am the average man, I can expect some testosterone to return in mid November at the earliest, then a slow build up from there.  I still have no libido so I don’t feel frustrated by this (although bedroom action continues when prompted, and I have no ED –strange, eh?)   I suppose I can think of this study conclusion as showing ‘free’ continued PCa suppression / enhanced radiotherapy killing potential without the jabs.     AW
  • Great Post, thank you  

    The more I think of my situation, the more I see "odd" things, for a start PSA182 and no spread. I could never get my PSA below 0.29 on 3 years HT. I had my last 6 monthly jab on 7 June 2024 and by the end of February 2025 I know my testosterone is back in full Innocent. (I haven't had a test but trust me - or ask Mrs M - it's back!! Joy).

    I just think I have a strange set of results - even on my recent scan there was no sign of the cancer even though I have a rising PSA!

    Anyway, you and Mrs AW have something to look forward to!! Upside down.

    Kind Regards - Brian.

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  • The important lesson here is that when you’re signing up to “12 or 18 months hormone therapy”, that isn’t the full information.  Hormone therapy will take you down to “castrate” levels of testosterone. But these levels will persist way beyond the “12-18 months”, as testosterone takes a long time to recover.  However, as I’ve said before, this is accompanied by a lack of libido, so you don’t miss it as much as you would think.  Bedroom action can still happen (with encouragement).  But - lack of testosterone can also have other effects in some men (fatigue, bone thinning, weight gain etc) so it’s important to go into this line of treatment fully informed.  Hence this post.  AW

  • Hey AW, I recently took a T home test and at age 72 mine came in at 12.7nmol/L 9mths after cessation of my ht.

    Home test kit was easy and not expensive. 

  • Hi  - how long were you on HT?  Was that 9 months after your last jab, or 9 months after the 3 months effectiveness of the jab (ie 12 months after the last jab)?  AW

  • I was on ht for 7mths and it is now 10 mths since the last jab

  • Ah, only 7 months - so that’s pretty much in line with the survey.   AW