Latest PSMA scan shows Abiraterone and ADT not working

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Hello everyone, my scan is shown below which I don't fully understand. My PSA had gone from <0.4 to 1.4 in 4 months.

\There is persistent GA-68 PSMA avidity in the prostate gland extending into the right seminal vesicle. The extension into the seminal vesicle seems more today than previously. There is a new small avid proximal right common iliac node SUVmax 30.5. There are multiple small distal paraaortic n aorto caval nodes e.g. posterior aorto caval node in front of L3/L4 disc space SUVmax 9.3. There are no further GA-68 PSMA avid retroperitoneal lymph nodes.

The hepatic distribution of GA-68 PSMA is unremarkable.

There are no GA-68 PSMA avid lung nodules. There are no GA-68 PSMA avid hilar or avid mediastinal lymph nodes. Small new avid node left of the left Thyroid SUVmax 4.4.

There is a new intensely avid L4 vertebral body lesion.There is a new avid small lesion in the left sacrum, adjacent to the upper left SIJ. Right iliac mestasis SUVmax 108 today, previously 150. There are no other GA-68 PSMA avid skeletal deposits. The distribution of GA-68 PSMA elsewhere is physiological.

I will start Docetaxyl in 3 weeks time to have 10 cycles every 3 weeks. Options running out!

  • Sorry but you lost me in all of that, all I know olive got advanced prostate cancer that’s gone to my bones quite extensively. Gleason factor nine PSA 16.8 went down lower but had to take me Zytiga because of low calcium in the blood so went up to 21.

  • My dad jumped to 285 whilst on abiraterone when it stopped working he was deemed unsuitable for Docetaxyl (90 yrs old) but thankfully bupa has funded another treatment which is keeping him pain free and dropped his PSA from 285 to 41 on first round in December so waiting to see if the 2nd round in January reduced it further 

    but just looking to keep quality of life at his age and prognosis 

  • That's interesting. What treatment is your Dad on via Bupa, if you don't mind me asking?  

  • Sorry to read this Rich. You seem to have a few active metastases. Sincerely hope the docetaxel brings things under control again for you. 

    Ido4

  • Thanks Ido4. I've not had any pain before but that's is going to change now I presume. I have looked at the average life expectancy extension given by Docetaxel and it's only 0.89 months! Hopefully that includes old data and older gentlemen. I am now looking to retire when I am 55 in June as the "tools" are running out!Slight frown

  • You are quite right to retire. One of your results showed a drop in uptake from 150 to 108 which is good. Hopefully the docetaxel will give it a kick in the teeth and allow hormone therapy to work again. Cabazitaxel is there as an alternative chemotherapy. Might be worth looking to see if you are suitable for a trial too. 
    I wish you all the best with this, take care. 

    Ido4

  • The Uptake in my RH Ilium was 150 but I then had 5 sessions of SABR which brought it down but it's climbed back up to 105 since that treatment. 

  • Ah, I hadn’t realised that Rich, sorry. 

    Ido4