CA125 and Chemo

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Hi. I have been diagnosed with stage 3c ovarian cancer. I had de-bulking surgery eight weeks ago where all visible cancer was removed. I am due to start chemo next week. My CA125 was originally over 1000. It then reduced to 254 just prior to my surgery and this week is 39 so almost normal. I know this can be an unreliable marker but that it is used during chemo to measure its efficacy. As it is nearly normal I am wondering if having chemo is worth it due to the risks involved, particularly as my spleen was removed during surgery so I am already immune compromised. I guess it should be a discussion with the oncologist but wondered if anyone else had had the same experience. Thanks.

  • Hi , sorry to find yourself here, I'm stage 4b as I also had my spleen removed. Personally I would have chemo as it completely kills any microscopic cells that linger and will give you a better chance . I'm thrilled your CA125 has dropped so well, but you now want it to remain they way. 

    I've just had my first chest infection after cycle 4 , I've been given a strong dose of antibiotics and have recuperated really well.  

    The best advice is to chat to your Onco and follow their advice.

    All the best 

  • Hi thanks for the response. Sorry to read about your infection but glad you are responding well. I have had my first chemo and am on day 7 post it. Have felt pretty awful so far, numb fingertips, heels, severe fatigue in that I can hardly walk sometimes, that may be the filigrastin injections or a combination of those and the chemo. My body feels like it is really numb, is this all usual and does it get any better during the cycle? I really hope so. I had an allergic reaction to the paclitaxel so I was pumped full of steroids. I guess the chemo is doing some good (I would hope) as it is so hard to allow such toxic nonsense to be swimming around. A real dilemma. I have been told I need to have at least four carboplatin to qualify for naripbabib (something like that…) x