Hi everyone. I'm part of this forum, due to my dad sadly being diagnosed with pleural mesothelioma 2 years ago. It wasn't detected straight away.We had to wait for at least one year before the doctors confirmed that it was pleural mesothelioma. Since then, he has undertaken chemotherapy, which has helped with some pain due to the cancer spreading on the sciatica nerve. He did carbo/pemetrexed for 6 cycle. He then stopped and pet was encouraging, the pain had gone down. We were happy. After 3 months new scan and he had to restart, this time on another chemo. It didn't work and he stopped it after 2 months. He ended up on the wheelchair because unable to walk due to the sciatica nerve pain. New scan confirmed disease progression. The doctor proposed immunotherapy with nivolumab, he has had about 3 cycles by now, but after only one week from it, we realised he was losing the sensitivity in his hands. Day by day this has worsened, to the point he is now not able to move arms or hands or fingers. Almost completely paralysed. We have to feed him, clean him, everything. He is only 62 and the strongest man I have ever seen.
So this is my question for you: has anyone witnessed a similar situation? Paralysis of arms or legs, like a collapse of the muscles? Can this cancer or the treatments debilitate you to this point? I am over concerned and struggle to think this could be the end 
. Thanks so much
