Lesions in liver

First of all I am sorry you find yourself here. Although I have a different cancer (TNBC), I had liver mets and maybe I can offer some hope. I first found I had spread to my liver 3 years ago. Like you, I thought it was the end of the world. I looked up stats and they were not encouraging. I decided I wouldn’t ask for a prognosis as I didn’t want a use by date hanging over me. 

Initially I had a biopsy with microwave ablation performed at the same time. Unfortunately the ablation wasn’t successful, but the biopsy confirmed my mets were from the TNBC and were PD-L1 positive, same as my primary tumour. This made me a candidate for the immunotherapy drug Pembrolizumab. I was treated with that, along with NAB-Paclitaxel for a number of months. Not plain sailing as I had an immunotherapy adverse event that caused kidney damage amongst other things. But the treatment significantly shrunk the mets and we tried a second ablation. I have been in remission ever since. 

Immunotherapy drugs like Pembrolizumab have changed the paradigm somewhat. Nothing is ever described as a cure, but some patients do respond extremely well and can achieve sustained remission from them. They can also cause serious collateral damage too, as I also experienced. 

On your question of whether a liver biopsy hurts, I can only answer for my ablation procedures. Done under general anaesthetic, they leave you pretty sore and in pain if you bend for a number of days. But you are back to normal fairly quickly. 

I hope my case can give you some hope. I don’t know whether your cancer is amenable to pembro or a drug in the same class.  If it is, read up on how the drug works as it helps you understand the risks. In my case I had a fairly small amount of cancer in my liver, nothing elsewhere, and I wasn’t dealing with any other symptoms. 

Hoping there’s a way forward here for you.