Hi all. First time posting here and not sure if it’s the right place to ask this question. But there seems to be a difference of opinion between my oncologist and surgeon about whether I should be taking letrozole, and I’m sort of caught in the middle and don’t know what to do.
I just finished 6 rounds of this chemo+immuno and my oncologist has started me on letrozole as my two lumps are hormone driven (E+/P-). But at my pre-op appointment today, the surgeon said letrozole isn’t usually prescribed for tumours smaller than 1 cm, which is luckily the case with me, and advised me to query it with the oncologist.
Anyone experienced similar discussions or have any advice on dealing with contradictory opinions from medical staff? I feel uncomfortable challenging their professional opinion but of course want to make sure I’m doing the right thing. Thanks for any words of wisdom.
Hello, I have never heard that letrozole or any of the hormone blockers had a size limit to be recommended. I live in Florida and had a small 3mm IDC with 6 mm DCIS in one breast and DCIS in the other. Both were ER and PR positive so have been on Anastrazole. Both the surgeon and medical oncologist agreed on prescribing me the hormone blockers for 5 years.
Definitely an important question to have clarified. I would want to see study results too and have never seen this issue studied.
Take care snd be well.
Barbara
Thanks Barbara. I’ve searched online and also can’t find anything on a size limit for prescribing hormone blockers. So I’m inclined to just stick with the advice of the oncologist and not query anything. Better to do too much than too little. And other than night sweats (which I already had anyway) I don’t have any side effects from letrozole yet, so think I’ll just carry on.
Im in the Netherlands btw, so interesting to hear how the advice might vary per country.
Take care and hope you’re doing well.
Beck
Hi to you and I also find it interesting to see the different protocols in countries. So glad you are not experiencing any of the other symptoms from the AI’s. I have some from Anastrazole but am carrying on with less than 2 years to go. Vaginal dryness was a big issue and it is called genito urinary symptoms of menopause or GSM.
So hot and humid here and really sick of the heat. Got a few more months and then cooler weather. Hot flashes and hot weather are awful.
Barbara
Hi Beck,
I’m another who hasn’t heard of letrozole prescription being related to tumour size. I’ve understood that oestrogen receptivity, grade and proliferation potential were key.
Once you’ve had the lumps removed pathology on the tissue taken should confirm what is known about your cancer and also give further detail for your oncologist to work with when deciding what best to prescribe.
Since the surgeon has suggested you ask about the letrozole, it shouldn’t be a problem to do so- I would tend to go with what the oncologist recommends in the end.
All the best xx
Whatever cancer throws your way, we’re right there with you.
We’re here to provide physical, financial and emotional support.
© Macmillan Cancer Support 2026 © Macmillan Cancer Support, registered charity in England and Wales (261017), Scotland (SC039907) and the Isle of Man (604). Also operating in Northern Ireland. A company limited by guarantee, registered in England and Wales company number 2400969. Isle of Man company number 4694F. Registered office: 3rd Floor, Bronze Building, The Forge, 105 Sumner Street, London, SE1 9HZ. VAT no: 668265007