Tamoxifen and Topical Vaginal Oestrogen

P.s. I found a paper on vaginal moisturisers after breast cancer and it said that they frequency of use needs to be more than in the case of a natural menopause.  Every other day instead of every 3.  I changed to using it every other day and it made a massive difference toitseffectivenes.  X

Ah that's great to know. Thanks again! 

Hi

I started using Vagirux in January this year after almost a year on Tamoxifen. It's really helped me.

I was anxious at first, but my oncologist, my surgeon and my GP all agreed It's safe to use. I also trust Liz O'Riordan's advice and she confirms it's okay too.

All the best

Hi, thank you so much for sharing this.  It's really good to know! Have a great weekend, S

Thanks, I’ll give that a try

This study is relevant.

pubmed.ncbi.nlm.nih.gov/.../

Yes this was an excellent study and the issue for me is I am on anastrazole and there is a risk of recurrence on vaginal estrogen treatment while taking AI’s.  My medical oncologist said no vaginal estrogen for me as my tumor  and DCIS were both 100% estrogen and progesterone positive.  I use a hyaluronic acid vaginal suppository every 3 days snd that helps me.  I am sure the vaginal estrogen would work better but I don’t have UTI so ok for now. 
Barbara

My tumour was ER +8 and PR +7.  After considering my nomogram results I decided not to have endocrine therapy.

I did take ERT for 20 years, so do not match the selection criteria in that study.  I am still gathering information to consider whether the benefits outweigh the risks.  I have VA and persistently high leucocytes as well as a recent UTI, which indicated resistance to a number of antibiotics.  I, therefore, feel I need to be more proactive in my approach to the problems.

I did note that statistically there was a potential risk of recurrence for those on AIs, but not on mortality.  Depending on how long you have been on the AI I think it is possible to switch to Tamoxifen, but there again it is a risk calculation.  I thought DCIS tumours were less threatening, ie stage 0.

I will have to have a look at h a v s.

Hi - I have been treated for hormone positive breast cancer and am on Tamoxifen. I am also using Estradiol pessaries which each health professional I have spoken to have said is now considered to be 'safe' as the oestrogen has a highly localised impact. I am not using a topical one but a tablet placed in my vagina 2 times a week. Seems to be working. Good luck.

Hi C21survivor, thanks for replying.

According to a 2022 Danish study you should be in a good position as you are taking Tamoxifen.  It is a SERM which should protect your breast tissue from the oestrogen should it pass into your system, during the loading period for example.

I am in a different position because I am not taking endocrine therapy.

Good to hear you are experiencing a benefit.