My oncologist has recommended that I have Carboplatin and Paclitaxel for my liver metastasis. She has said that for anal cancer the evidence is that it is most effective if given on a 28 day cycle of:
Day 1 - Carboplatin and paclitaxel; Day 8 just paclitaxel; Day 15 just paclitaxel and then two weeks off before repeating the cycle again on day 29. Presumably the paclitaxel dose is spread out across the three infusions.
Has anyone had it like this? And if so, what can I expect in terms of side effects? I know everyone reacts differently but I can’t find much about whether people have experienced more or fewer side effects having it this way as opposed to the more standard everything on one day of a 3 week cycle.
Grateful for any hints, tips or insight please. Many thanks.
Sarah x
Hello Crystaltipps73f2a8
I had exactly this regimen after diagnosis as I was already stage IV, I think we have spoken before. But in all honesty, this was so much easier than the chemo/radiotherapy. After the very first infusion that evening I definitely had a moment of chemo brain where I couldn't string two words together, but that only happened once. Fatigue, a bit, but again, not like what came with the combined therapy. I looked over my notes from that time again, and after a session I definitely had constipation quite badly. So I would get prepared with a supply of Laxido (which is gentle) to take on the day of treatment, and maybe the day after. And the steroids (for nausea) definitely kept me wide-awake the evening following treatment that day - late-night housework and television ruled!
After the first session I had to miss a week as my liver levels were out of kilter but my oncologist was unperturbed and said it was just my body reacting to the chemo. She reduced the dose to 75% thereafter and I was fine.
I still walked my dog on non-treatment days (six miles a day) and on occasion even walked the eight + miles home after treatment.
Sarah, if there is anything else you think I can help with please shout out. Wishing you all the luck, please let me know how you get on.
Irene xx
Thank you so much Irene - that’s really reassuring to hear. There seems to be so little information that it’s so good to hear some real life experience. I think we (husband and I) are just trying to work out whether I’m likely to feel well enough to do things/go out during treatment and this sounds like I will. We love to walk so your being able to walk 6 miles a day is very reassuring.
Yes we have spoken before and you pointed me to your lovely Etsy hat lady. I’ve had a chat to her and will look to her for help after I’ve seen my hospital’s hair advisory clinic.
I’ve got loads of Lacido that I was given for my last treatment but never needed to use, so I’ll have them ready to take!
thanks again - really appreciate the tips.
Sarah x
Hi Sarah I've had it but not onaw8 day cycle.i had it every 3 weeks .6 cycles but it was effective .hope all goes well xx
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