No idea how to deal with nephews cancer diagnosis

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I have an extremely close relationship with my parents and younger brother. He has two children who I treat like my own. I also have two children and they are so close to my niece and nephew. 

we had just found out that my nephew has sarcoma. It’s completely devastated us all. We don’t know what stage or the treatment plan yet.  

I have been the practical one trying to keep everyone together. My parents can’t show my brother their pain so have turned to me. Every person that I love the most is hurting. 

I have no idea how I’m going to tell me children. My eldest has huge anxiety and separation issues and her cousin is her best friend. 

Any advice would be greatly appreciated 

thank you