Neutropenic Sepsis, what next?

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Hi there

My dad is on cycle 3 of 4 chemotherapy (Cisplatin and Etoposide) with a 3 week radiotherapy which ended 3.5 weeks ago. Last Wednesday he got admitted with neutropenic sepsis (between 2 and 3 he also got admitted with a severe infection and was in for 3 days but this has been much worse). His 4th chemo was originally due 20th March, but got put back due to 1st infection, so was then 27th March but that has now been cancelled and we think it's very likely he will be in hospital for rest of the week before coming home on antibiotics, so chances are it won't happen next week either. He's really fed up and we're all concerned as to how serious this was, on the back of having an infection last time around too. We're due to have an apt with his oncologist hopefully next week to discuss options, but just wondered what peoples experiences have been? Has anyone had neutropenic sepsis then continued with treatment? Anyone stopped or shortened their chemo for this or other reasons? What questions should we ask? We're really worried that next time it could be fatal and looking to the oncologist to tell us the risks vs benefits etc of this last one, considering it will be at least 3 weeks delayed by the time it can happen. 

Would really like to hear anyone's experiences 

Thanks x

  • Hello,

    it’s not great when you get admitted. 
    I got admitted last year after my 5th cycle - a couple of days after my birthday with suspected neutropenic sepsis. It was scary. Spec the rest of the chemo - I was so paranoid. 
    Chemo still went ahead and I got a throat infection on the 6th one (I’d already done 12 weeks of another 2 chemos before changing) - I didn’t get admitted. 

    I finished all my chemo and I know others who have been hospitalised and finished theirs too. 
    It may be that the oncologist reduces the dose possibly? 
    They may omit the last one? 

    I had 2 omitted in my first batch of chemo cos of liver enzymes…

    I hope dad is okay and home soon!xx

  • Hi - Is you dad getting any prophylactics with the treatment? My treatment made me neutropenic every cycle so I was taking aciclovir, fluconazole and co-trimoxazole on a daily basis. I didn't get any infections during treatment and that potentially helped. 

    Obviously each case is different and liver and kidneys are already working overtime so adding three more drugs is not always helpful... But might be worth checking with the clinical team if they haven't already given him these.

  • Hi I have just come out of hospital after four weeks. Had sepsis and DRESS, they think it’s from immunotherapy but could be chemo so I can no longer have either.

    hoping to get off the steroids soon so can go straight for surgery, it’s all very scary but they see it a lot and know what they are doing. I had a scan and the chemo Iv already had has shrunk it a lot so I’m trying to be positive. 
    I wish your dad well 

  • Thanks all for your replies, it's reiterated to me that cancer is a very personal journey, but it's given me some stuff to consider and float by the consultant when we hopefully see him next week. 

  • Hello, my husband is in similar situation. Has oesophageal cancer and very weak as can not swallow. Due to start round 4 of chemo next week which gets every 21 days,  but on Sunday had to get emergency services, very low BP, oxygen etc. Now in hospital with neutropenic sepsis. On a IV fluid drip and intravenous antibiotics. Told if I hadn’t called emergency it would have been a very different scenario, it was that serious.
    Yesterday was slightly brighter and managed a bit of conversation. Has been spitting up a lot of mucus which I suppose is good to clear chest but so horrible to see them struggle.  Been told doing no more chemo but are going to a CT scan which will determine if chemo has been working. so maybe they hopefully will resume Fingers crossed
    it is a very frightening situation for patient and also family. 
    Not sure how long will be in hospital so it is day at a time  

    I hope you get good news soon  x

  • Hi there, I'm sorry you're going through this, it really is tough beyond words. We're a few weeks on now and he's had last chemo (at least for now) and so we're just keeping everything crossed that he doesn't get another infection, as we don't feel that mentally it would be good for him right now, he just needs a break. We're supposed to get married next week which we brought forward so he could be there but if an infection happens we'll have to move it. His temperature was up and down yesterday, and we have different opinions as a family as to what action to take... so just keeping everything crossed for a myriad of reasons. 

    For you what I would say is whilst the mucus feels endless it does stop, the NS is super scary but you've got it in time and that's the main thing. I hope you have some support around you as me and mum tag teamed the hospital visits and were still knackered. Hoping for a good scan news for you.