MMR Proficient and ERPR positive

I believe MMR proficient is a good thing as I had a MMR deficiency which refers to the Mismatch Repair process, now they are trying to figure out what has caused this . Regarding the ERPR, I was given a score of 4/8, I am not that clear on the significance of the hormone receptivity significance, but I know when the pathology of my hysteroscopy was 0/8 ERPR they were not concerned about my risk of Lynch Syndrome, but they wanted to test for that once my hysterectomy pathology was coming out as 4/8 and some MMR deficiency.

Hope I haven't confused you more

Thanks B74.

I read this on my discharge letter but nobody has explained it to me so that was helpful!

Is there any correlation between these and the BRCA genes, do you know? I know that my doctor wants me to undergo genetic testing, so I'm presuming not given that he already has the above info.

I'm afraid I don't know about the BRCA gene, I am still waiting for my appointment with the genetic clinic. However, there are many others here who will probably be able to help. It would also be worth using the support line or online chat and asking a nurse.

Hi Glass Not Full

Best person to ask to explain is your CNS or you could give the Support Line a call tomorrow (8am-8pm) and ask one of the nurses to explain.

My understanding, through discussing with my own consultant is that MMR proficient could be considered favourable as its a sort of repair gene. (mix match repair) 

ER/PR positive can also be seen as favourable. However on their own they do not give the whole picture. 

So my understanding is that all these different factors when put together help them decide which treatment to offer and to help them decide whether recurrence could be a higher or lower risk and then they can look at how the cancer could respond to chemo, radiotherapy, hormone treatments or immunotherapy. So for eg; if someone is ER/PR positive it would suggest that they may respond to hormone based treatments

We are not medically trained on here though, so best to check with someone who is.

Jane