Failed to take biopsy

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Hello I am hoping someone will have had a similar experience at a scanning clinic.

I have adenomyosis so forewarned them they may not be able to measure the endometrial thickness. I tolerated the TVS fine and they very quickly said let’s go straight to biopsy, but with the speculum I got a lot of pain when it touched the cervix. The clinic wouldn’t continue with the biopsy. I said I was happy to give it another go, but they said it wouldn’t work due to the cervical response.  

I have been booked for a hysteroscopy under general next week.  I’ve had at least 4 hysteroscopy attempts before, and 3/4 have not been completed. One of the failures was also under a general anaesthetic.  It is a different gynaecologist so what do you reckon the chances of a successful biopsy are?

I would really like one as I have had a really heavy post menopausal bleed, and veins and tissue were also passed.  This started 25/3/25 but I had a small bleed last year too. I had been on Zoladex for over a year but stopped in November 2023 so there is a chance it’s hormonal.  Better to know what’s up in my mind.

Any thoughts, advice etc gratefully received. Playing it cool is getting harder…

Cheers 

  • Hi Jem25

    I am sorry to hear that your have been having some bleeding and there have been difficulties obtaining a biopsy.

    My experience was different to yours in that I went for an ultrasound and then when something was found, I was called in for a biopsy on another day. I did not have a hysteroscopy as there was too much bleeding so it would have been difficult to visualise and because something had been picked up- they went straight on to biopsy it.

    You are not alone in having failed hysteroscopies. It is important for them to do the biopsy and although it has been failed before , it doesn't mean to say that it can not be done this time. Hopefully the general anaesthetic plus the knowledge of the previous failed hysteroscopies will mean that the new doctor has a chance of preparing for it to be challenging. 

    If they are unable to do the biopsy samples then I would imagine that the next step would perhaps be an MRI of the pelvis. 

    I wish you well for the procedure next week and hopefully they will be able to get what they need to. 

    In the meantime, we are here if you need us.

    Jane

           

    Macmillan Support Line - 0808 808 00 00, 7 days a week between 8am-8pm

  • Many thanks for the kind response. They are planning to take biopsies with the hysteroscopy so I am hoping it can happen.

    Pelvic MRI have worked in the past it just all extends the waiting game and stupidly I worry about that.

    It is just lovely to feel there is a safe place for a quiet fret x

  • Fingers crossed - if the hysteroscope can get in, then the biopsy should be able to be done. 

    Yes, its a safe place to put your worries. 

           

    Macmillan Support Line - 0808 808 00 00, 7 days a week between 8am-8pm

  • Just an update.
    A successful hysteroscopy on Friday despite a very stenosed cervix and a scant sample taken as the endometrium was very thin. No polyps seen.

    They said if the sample came back as insufficient that it would taken as a good result and no further action would be needed. 

     Very little pain, and bleeding post procedure. 

    I thought I should post this so anyone in a similar position to me would see that on a different day with a different person it was possible.

  • The fact that your lining is thin is good and so glad they got this done! I had a very steonosed cervix but they still managed to get a sample, 3 times now. It's worth sticking with it. Hope your results are good.