Immunotherapy for endometrial carcinosarcoma?

Hello yr1982

I was started on chemo, carboplatin and paxlitaxel, after diagnosis of stage 3c2 endometrial cancer.

I did experience peripheral  neuropathy, and the doses were altered. I do still have a small amount of numbness, but it is very mild.

After my operation and radiotherapy, they found my cancer was still progressive and I was started earlier this year on Immunotherapy. It was Dostarlimab, it specifically targets endometrial cancer. There are still risks involved with immunotherapy treatment.

After two treatments, I did suffer some serious side effects and treatment stopped to address these.

Whether or not I get back to treatment is still unsure, but it did have an effect on slight shrinkage of tumours just after two doses. I'm hoping I can eventually get back on it.

It may be worth discussing options with the Oncologist, or MDT, to see if this treatment is suitable for her. 

I hope you have success

Please keep us updated.

All the best

Shellie

Hi I have the same type of cancer as your mum, mine was all contained to the womb but it managed to get into 3 lymph nodes.  I had a full hysterectomy in November and I finished chemo in April.  Two of my lymph nodes haven’t changed since my first scan in September and one has shrunk, I am currently stable so the oncologist is happy for me to not have any more treatment unless needed.  My oncologist was going to email the christie in Manchester to see if there was anything else she may have missed but I haven’t heard anything yet.  I hope you and your mum are coping well with everything. X

Hi yr1982. and welcome to you and your Mum to the group.

Paclitaxel and Carboplatin are the two drugs normally used for this chemo. Often 6 cycles every 21 days. I now suffer from peripheral neuropathy as a result of the Paclitaxel but they can "tweak" it a bit apparently.

I did ask my Oncologist if Immunotherapy was an option for me but was told not for my particular type of cancer (Endometrial Adenocarcinoma serous grade 3) but ask, it may be a good option. Dostarlimab is having very positive results. No doubt there'll be some side effects as I've read Shellie69' s post .If you type Dostarlimab in the search bar at the top of the page you should get some results.

It’s always helpful to others if you write a little something (or a lot) about you and your Mum and how you came to find yourselves here. Why not take a few moments to update your profile. It's always helpful for us to read if we want to ask you questions and you also won't end up repeating yourself. You can enter it into your profile (click on your username and select “Profile”) . You can amend or update it at any time. If you’re not sure what to write, just click on my username.

If you want to ask any of us any questions please come back and do so. There's always someone around and we can offer a shoulder to cry on, a hand to hold or listen to a rant, we’re here for you.

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Sending you welcoming hugs, Barb xx 

Hello Shellie.  Thanks so much for your message and I'm really sorry for the long delay in replying my end.  Mum decided to go with the chemotherapy offered and starts tomorrow.  I'll let you know how she gets on.  I hope your doing ok and wish you every success to.  All the best to you, Jordan x 

Hello.  Thanks so much for taking the time to message me.  I'm so glad you're currently stable.  Mum is doing ok and decided to go for the chemotherapy offered.  She starts tomorrow.  I'll let you all know how she gets on.  She's seems ok at the moment.  Best wishes, Jordan x

Hello Barb.  Thanks you so much for your lovely message with all the information.  I'm really sorry for the delay in replying, but I'll make sure I fill in my profile over the weekend.  Once again, thanks for taking the time to reach out.  I'll let you know how mum gets on - she starts chemo tomorrow.  With best wishes, Jordan x 

Hello

hope you well x my mums in a similar situation. She completed chemo last Aug and is on a 2year trial of Atezolizumab.  She’s receiving the trial drug at the Royal Marsden.  So far, the chemo and iotherapy drug have zapped up the nasty cells.  Praying things stay as they are….

happy to share further details. Let me know xx

lots of love to you and all the lovely ladies on this forum xxxxxx

Hello, I'm so sorry, I just realised I didn't reply to your message.  I'm so sorry about that.  I hope you and your mum are ok?  My mum has completed her chemotherapy but has to have more scans as she has a nodule in her vagina and one of the lung.  They did biopsy her vaginal nodule during the chemo but said the biopsy was 'non-diagnostic!?'  Happy New Year to everone.  Jx