PSA rising, now starting Cabazitaxel

1. hi im sorry to hear this. I'm unable to give any advice to your query but I to finished triplet therapy in July, I was also 59 when diagnosed,  as im only a couple of months behind your husband could I ask were the cancer has spead to . I no this is of no help to you but it may give me an idea of things to come. stay strong, regards dale

Hi Dale,

Sadly it has spread to the hips, femur, ribs, shoulder and base of the spine. He had no symptoms other than a back ache for a week when he was diagnosed. 

All the best with your treatment. 

hi thanks for the reply.  same places as me then . first sign for me was a snapped clavicle whilst working.  likewise all the best with his treatment please keep us updated  

Hi Cornwall12, depending on circumstances, and if you haven't been on them before, Abiraterone and Enzalutamide, in that order, though your cancer can build up a resistance on Abiraterone to Enzalutamide as though they are different treatments, they both target the AR pathway, you may go straight onto Enzalutamide, but this will likely rule ot Abiraterone as results are negligible, whereas the other way round some get a good response.

Eddie 

Thanks so much Eddie for your response.

Are these drugs normally taken whilst having chemotherapy?

Abiraterone used alongside cabazitaxel has shown good results, the results of using Enzalutamide with cabazitaxel are inconclusive and the combination is a very powerful one which can be difficult to tolerate so a sequential approach is standard, and more effective.

Eddie 

Thank you so much Eddie