My Journey with Advance Prostate Cancer on Clinical Trial

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Hello fellow friends,

Now I was diagnosed in 2018 with Advance Prostate cancer my PSA was 24.44 Prostate biopsy was Gleason 4+5 involving 6/6 cores in right lobe and 3/6 in left lobe with tumor of 14.1mm. 

I was asked if I would like to go on a clinical trial which I said yes, this was inserting gold pellets around the tumor and having 6 weeks of radiotherapy and also radio on my pelvic bones to stop any trace of the cancer going there.

My prostate can not be removed as the cancer has gone to the outer rim area. I also was on at the time and after Tamsulosin, Bicalutamide, Metocloramide, Prostap SR DCS 3.7mg injections.

After all treatment my PSA levels from 2018 till 2022 was a great 0.07/0.12/0.28 until last year 2024 rise to 4.28 then last month (Feb 2025) I was sent for a PSAM

Pet scan in Liverpool. Results show a slow growth back in the prostate but 2 very small tumors on the lymph nodes near the prostate, my PSA now is 2.98. I have now been told that any other treatment is not on the table the only treatment I may have now is hormone injections. I have a choice to make do I take the injections now and have all the side effects back form the hormone injections or wait and see if the tumor grow and then start on the hormone injections as it may be a couple of years before any growth or they may grow straight away? Well there you go has anyone had or are having the same dilemma to choice from and do I get a second opinion on can I have anymore treatment.?

  • Not got a similar dilemma, however I do have advanced PC to my prostate and lymph’s (no bone involvement at the moment) I had chemo and radio last year plus Zoladex HT injections. My current PSA is 0.05 

    Personally I have found the HT ok. I get the odd hot flush here and there, but apart from that not much. Of course the thing it does affect the most is libido, that’s pretty non existent. I of course have no choice because I will be on this stuff to keep me alive for the rest of my life. 

    in your case I guess it’s a choice of odds. Don’t have it and risk it spreading. Do have it and face the consequences of some side effects, if it were me (and of course it’s not) I’d probably go for the ADT injections. Best of luck whatever you choose!