What is so special about PSA 2?

  • 1 reply
  • 114 subscribers
  • 83 views

I was diagnosed 3 years ago with a PSA level of 12. After 2 years of active surveillance (immediately before treatment) it was 15. Six months after the final HT injection and 3 months after RT it is 0.07 and I have been discharged back to the care of the PSA tracking team, with an action level of 2.

So obvious question. If 12 was ok for active surveillance, why is action needed at 2?

  • Hi  - the reason is that you have had the nuclear blast of radiotherapy through your prostate and so that’s why PSA is 0.07.  Whilst you still have a gland, it is not the same gland as before radiotherapy (won’t produce fluid, for instance).  Think of it as a nuclear wasteland of scar tissue, which used to contain active cancer cells (now dead, as they had their DNA twisted by the radiotherapy so were killed off when they tried to duplicate).  You’re left with prostate cells still alive and they can still grow and will produce much smaller amounts of PSA in this wasteland of a (non functional) gland. The level of 2.0 is set, because if it’s higher than that, it will be coming from elsewhere, other than the gland. A 2.0 would start the diagnosis again, with -ideally - a PSMA PET scan to see where in the body the PSA is coming from (ie where the escaped prostate cancer cells have managed to hide and grow, outside the gland).   AW