My partner has been on enzalutamide for about 8 months. He had a spinal cord compression in October and has been unable to walk since - he was progressing in hospital, able to move his legs but with little muscle strength. He was discharged in November due to a covid outbreak, since when his physiotherapy has fallen from daily to once a week (if he's lucky). He has some exercises to do, and recommended to at least stand every day using the transfer aid, but is mostly too tired to attempt it. The oncology registrar today suggested they are considering a break from the enzalutamide, to increase his QOL, and that chemo would be an option if he were stronger. Does anyone have experience of taking a break from enzalutamide? Would it shorten his life expectancy? His PSA has risen from 8 to 25 since November - does this indicate the enzalutamide is no longer working? We don't know if his inability to increase his mobility is due to the spinal cord damage, the lack of physiotherapy or the fatigue from the enzalutamide and/or the cancer.
