Bicalutamide Tablets

FormerMember
FormerMember
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Hi All 

My hubby recently started on Bicalutamide tablets..7 days ago....He is going for a hormone injection next week and currently waiting to see oncologist. Prostate spread to nearby lymph node. His bone scan was clear..  since starting these tablets he is experiencing great fatique....do any of you lovely guys experience the same tiredness ? Any tips or hints ? Thankyou so much and good evening 

  • Unfortunately fatigue is a well known side effect of Bicalutamide. However, if he is moving on to hormone treatment then the Bicalutamide will finish in a couple of weeks. It is important to try to take exercise as this can help with the fatigue. Walking a couple of miles a day will help a lot. He should also take a rest in the afternoon.

    I hope that helps.

    Yesterday is history, tomorrow is a mystery and today is a gift.
    Seamus
    (See my profile for more)
  • FormerMember
    FormerMember

    You may find the Macmillan booklet helpful.

    You can download it from here

    be.macmillan.org.uk/.../p-24977-coping-with-fatigue-tiredness.aspx

  • I've experienced fatigue and problems with memory (silly things) I'm 50. But believe to poor sleep due to nocturnal toilet visits plus sub conscious worries at night 

  • FormerMember
    FormerMember in reply to YoungMan

    It's interesting to note that your husband is starting Bicalutamide first then having his hormone injection start later.

    For myself the two ran concurrently. Fatigue was a major problem, especially once the hot flushes kicked in too. At the time I was still working so I was active through the day, but found I needed to rest more often as a result. Needless to say I slept like I'd never slept before at night. He will find a balance in due course.

    Ed presented itself too. That was a delicate challenge in itself.

    It's early days and I wish you and your hubby all the best.

  • It is standard practice to give bicalutamide first to prevent “tumour flare” when the first HT injection is given. 

    That’s how it was organised for me.

    See the link https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/bicalutamide

    Ido4

  • That is how it should be done bicalutamide started a week to ten days prior to first hormone injection and carried on for may be a week after the first injection.  The first injection should be a 1 month injection followed by 3 monthly injections mine was a nightmare.  I got to the nurse for my injection and she said "How did you feel over the last month since your first injection - as the type of injection could be changed if side effects were bad.  Told her but i haven't had an injection yet this is my first!  "Oh.  Have you had the bicalutamide tablets"  No!  Then the biggest cods up was made when the GP said I should start the bicalutamide 3 days after the injection but have the 3 month injection there and then because they didn't have the one month!  Doesn't seem to have made a difference to me but really just shows you how bad some admin is and how little GP's actually know about the treatment.  OF course it would have been better if the urologist or oncologist could have been in charge or ordered the medication and injection but here it is left up to your GP what you get.  I hear that some GP's do not give bicalutamide at all. 

  • FormerMember
    FormerMember in reply to freefaller

    Oh my goodness that sounds a nightmare...my husband started those tablets 9 days ago and he goes for his first injection next Thursday...he is experiencing fatique since starting tablets. However looks like that is a big side effect. We have a long way to go but we are both positive although at times it seems so overwhelming but we see the funny side and crack on. Thankyou to this forum anf the replies it means a lot. 

  • Flightsim, I'm interested did you have to stop work or had you planned to retire anyway. I'm younger than you about to start chemo and hope to carry on working for many years to come

  • Every oncology consultant seems to have a different idea about the time between the start of Bicalutamide and hormone injections. Mine said I should have the first hormone injection three to seven days after starting Bicalutamide. My GP said the same (wonders will never cease) but did modify the HT to two 1 monthly injections followed by 3 monthly ones.

    There is also quite a lot of variation in the duration of HT itself. My consultant insists on three years, some only require two years and some will stop HT very soon after radiotherapy is finished.

    Yesterday is history, tomorrow is a mystery and today is a gift.
    Seamus
    (See my profile for more)
  • FormerMember
    FormerMember in reply to Seamus47

       There is indeed quite some variation in the way Bicalutamide and Hormone therapy is prescribed. Poor freefaller was involved in a right old fiasco. I followed the link given regarding the way Bicalutamide is recommended to be prescribed. However there is a caveat early on in the fact sheet under the heading “Taking Tablets”. It’s enclosed in a red box which I can’t reproduce on my tablet  it states -

    Taking tablets

    You must take tablets according to the instructions your doctor or pharmacist gives you.
        On the day I was diagnosed by my Urologist , I was told that I was to start my treatment immediately. I was escorted up to the hospital pharmacy for my prescription. I returned to my CNS as instruction. The prescription was for Zoladex La, (the 12 week dose), and instructed to take the Bicalutamide that same evening, and bedtime, as it can cause drowsiness. It also improves the absorption of the drug as it’s best taken on a empty stomach, so you can see that I was prescribed the two to run concurrently.
        The reason I was given by my Urologist was that HT can cause tumour flair in the first month, and the Bicalutamide is used to prevent this occurring, and I took my tablets in accordance to the instructions given by my Oncologist. 
        Regarding the question from youngman. I continued to work from last November, when I was diagnosed, until April,  when I stared my radiotherapy. I was still able to work up until that point, particularly as I had to save money to carry me over that period of time until I was able to return to work. Due to the nature of my employment, I travel great distances and I couldn’t risk not being able to reach my appointments for RT in good time. My health comes first, work second. Fortunately I work for a very understanding company, who have helped me since before my diagnosis. 
        I was initially to have three years of HT and 37 sessions of RT. It didn't quite work out like that. On the day I completed my radiotherapy I meet my Oncologist on an unrelated matter. He reviewed my notes, and told me that as I had a high initial PSA, and aggressive cancer, and my PSA had been rising since the New Year, (my PSAV was out of limits at one unit per month), I was to start Chemotherapy, and not to return to work. At the present moment I just started my 5th session of 6 sessions, and the steroids have kicked in hence I’m up at 04:00, having been awake since 02:00, and I’ve another night to go.
        If I had the cash, I’d happily retire as I’ve been very busy catching up on many personal projects, and haven’t missed work one little bit. Though I have to admit that I’m sure most of that is due to having enjoyed the good weather, and being able to get out and about some days, and others just spent resting and reading in the garden.
        Wish I’d written this in word and cut and pasted it as writing here cuts out the paragraphs and makes reading this unpleasant. Something perhaps Macmillan could resolve.