As previous posts, 46 year old, diagnosed with metastatic Prostate caner in April, on Triplet Therapy. A slight concern this week with my PSA rising from 0.438 to 1.08, just before my final chemo session which I had on Friday — doesn't seem a big increase, but still around 146%.
Obviously it’s a number I’d rather have seen continue to fall, especially after such a positive response from 309 at diagnosis down to 0.438.
Trying not to read too much into one result, but it’s certainly something I’ll be discussing with the oncology team.
Has anyone else experienced a PSA spike like this during chemo, only for it to come back down again?
Hi MRTWW lots of reasons for fluctuations as you go through intensive treatment regime. Could be something as simple as dehydration, or irritation from the effects of chemo. Remember that you’re on a long term treatment pathway and things take time to (a) work and (b) settle down. Let’s face it, you’ve just had your final session - your team won’t want to add any treatment so soon afterwards (especially as, presumably, you’re also on some effective hormone therapy). AW
Thanks and very true and yes on hormone therapy.
Hi MRTWW , please don’t worry about a fluctuation during chemo. There is a possibility of a PSA bounce as, when the bad guys are killed, they release PSA into the blood stream. I doubt your team are in any way concerned and generally they won’t start to look at your PSA trend until a few months after your last treatment.
Best wishes, David
Please remember that I am not medically trained and the above are my personal views.
I'm in agreement with others' comments so far - you need to bide your time and let the treatment work.
Often things don't happen quickly when you're dealing with PC.
All the best, Derek.

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