Side effects of HT

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My dad "watched and waited" for 8 years. The cancer has now spread to the bones, lymph nodes and spine. He has had one round of HT and PSA has dropped from 132 to 13. We are not sure whether to have the 2nd HT as the side effects increase each time. He is 89 and the side effects are worse with age.He has COPD and reduced renal function. Has anyone else experienced this?