How low should my PSA level go?

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So my history so far:

  • March 2022 was first diagnosis with a PSA level of 12
  • After 2 years of active surveillance PSA level was 15.5
  • Started HT in November 2024 and 2 months later PSA level was 1
  • 20 sessions of RT in March 2025, and 6 weeks later PSA level was 0.1
  • 13 weeks after RT PSA level is 0.07 

I've read about the PSA nadir, and PSA bounce. Lots of people talk about a PSA level that is undetectable, but is that the exception or the rule? What should I be looking for over the coming year or so?

  • my last PSA after my radiotherapy treatment was 0.01

  • Hello  

    So the Hormone Therapy puts the cancer to sleep. The Radiotherapy kills off the cancer cells - job done.

    As both keep working long after being administered your expected nadir or lowest PSA should be 18 months after your radiotherapy. 

    The general rule is once you have reached your nadir no further action should be required unless you have 2 PSA tests in a row showing a rise or a rise of 2 whole points.

    We are all different and all have a different nadir (mine was 0.29 and that was after 3 years HT!). It's not something you can generalise as humans we are not all the same!

    I hope that helps.

    Best wishes - Brian.

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  • Good question but the trend is a better answer.

    Going down or stable is everyone’s hope.

    Stay positive as yours is going down.

    And good luck with more good news. Bravo

  • Hi Agent

    I am assuming HT finished some months ago.

    As long as the PSA doesn't start an upward trend then everything ok.

    The first year at least a bit nerve-wracking cos u do keep wondering if PSA is ok.

    But of course your PSA level at the moment is great, don't worry if it moves up slightly, hopefully you are getting regular PSA tests

    Good luck

    Steve