Biopsy results.

Hi Hammer 

Sorry to hear but think it all depends what the MRI says.

I presume that u had one previously, what did it say/show?

Do you have a TNM score because that can also tell you more.

Steve 

Hi Steve ,.

Thank you for your concern and help ,  

Ive cut and paste as its all double dutch to me.

Hope ive got right info . could not see anything that said TNM

Thanks . 

Mark.

Lesion 1
PC - Size Lesion 1: 16.5 mm
(06/06/25)

Prostate Gland Volume: 35
(06/06/25)

PC - Likert Score Lesion 1: 5/5
(06/06/25)

Prostate PSA Density: 0.2971
(06/06/25)
Prostate Region Lesion 1: Left sided
T4 lesion (06/06/25)
Prostate Lesion Present Lesion 1:

The prostate measures 35 ml.
PSA density 0.3.
T2 heterogeneity throughout the peripheral zone. There is a
dominant area of low T2 signal centred at the 7 o'clock
position measuring 16 mm (see key image), with mild capsular
bulging. Towards the apex there is further ill-defined dominant
low T2 signal extending from the 5-10 o'clock position (see key
image). This latter component extends down towards and
fractures the urethral sphincter.
Matching restricted diffusion and early enhancement.
Some haemorrhage within the left seminal vesicle.
No pelvic adenopathy. Unremarkable bladder and distal colon.
Right hip replacement. No bone lesion.

Greatest tumour length: 17mm
Other Pathology
High grade PIN: Yes
Intraductal carcinoma: Yes
Prostatitis : Yes, focal acute and chronic.
Conclusion
Tumour type: Acinar Adenocarcinoma
Highest Tumour Grade Grade Group: 5, Gleason score 5+4
Overall Tumour Grade Grade Group: 5, Gleason score 4+5
Overall Gleason pattern 4 percentage= 50%
Overall Gleason pattern 5 percentage= 30%
Cribriform pattern 4: present in D
Neuroendocrine expression: No morphological evidence on
H\T\E assessment
Maximum tumour length: 17mm Site: Target right posterior
Number of cores involved: Total: 10/14 ; RT: 6/7 ; LT: 4/7
Lobes: Both
Perineural invasion: Present (C1 C2)
Lymphovascular invasion: Absent
Extracapsular fat invasion: Absent
Immunohistochemistry: Not done
Suitable block for molecular tests: D2 (no necrosis, high
cellularity, 80%
tumour cells)

Wow, that's some MRI detail, I am no expert but there are a couple of people on here that are more expert than me.

However am trying to work it out as best I can 

So looks like a tumour 17mm , possibly near the capsule edge but not broken through.

Gleeson, yes highish but if still contained that does help.

Have they talked about treatment yet in particular to start you on HT to halt any tumour growth.

I think my working out is about right but apologies if not correct, hopefully others will come on here.

Anyway if I am right then still potentially curable 

Keep us posted 

All the best

Steve 

Steve,  

I only cut n paste a bit..there are  pages..

I'm clueless tbh with this at mo.

goin for Pet scan within next 10 days..

thank you for your time and your comments , really appreciated.

it's so helpful knowing I'm not alone.

cheers 

mark

I'm sure you'll get more replies, think everyone out sunbathing at the moment, just hang on , and keep in touch cos there's plenty of help and advice on here for you

Steve 

Hi Mark, 

You are not alone, 

Nearly all of us have been where you are, and it is a hard place. Nonetheless, this thing can be beaten, or at least held at arm's length for a long time.

There are a number of people here who can do very well with sorting that lot out, but I will offer a couple of comments. 

First off, my own Gleason Score is similar to your own. This really outlines the level of risk, but this risks suggests what will happen if the disease is untreated. Yours will be, so you can put side some of the concern. 

This web page explains the TNM system -  https://www.macmillan.org.uk/cancer-information-and-support/prostate-cancer/staging-and-grading-of-prostate-cancer

You will see that a T4 lesion is mentioned in the results, and you can see from the page above that this could be called "locally advanced" which isn't as bad news as it sounds.

I couldn't find a great deal suggesting huge spread of the disease, but there will be others with a greater knowledge along soon.

If you need to go through it in detail, then call the Macmillan Nurses on 0808 808 00 00, or chat with them online as instructed on this page - https://www.macmillan.org.uk/cancer-information-and-support/get-help/chat-online.

I have to say that I was told when I started to locate good sources of information, and then read EVERYTHING.

One of our friends on here, Alwayshope  has got a great way of explaining things, and will probably pick up this thread now I have taken her name in vain. 

She often recommends this document, which you can read online or download - https://issuu.com/magazineproduction/docs/js_prostate_cancer_guide_for_patients_ezine

I found it very helpful.

Thank  you for links and  your kind words,, it certainly  helps.

cheers 

Mark.