Zoladex

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I started Zoladex treatment 11 weeks ago. During the first 6 weeks I had 4 violent diarrhoea episodes and a painful and bloated abdomen. I eventually suspected Zoladex might be the cause. Went to GP. Usual tests, all clear, they now suspect Zoladex. Spoke to cancer team, they say this is not usual, but have stopped more Zoladex. Symptoms receding as I get to the end of the 3 month drug effect. Does anyone else have this experience?

Grantyo12 2 months ago

I have been on Zoladex since April, only thing I get is the odd hot flush and occasional aching. Top of my legs. Definitely not your symptoms though. Hopefully they can get to the bottom of it for you!

anubis 2 months ago

been on it nearly 6 yrs not really had a problem , other hot sweats and the usual other side effects

Ulfhbg 2 months ago

Hi !

Sorry to here your reactions to Zoladex (probably) and not really a nice start of hormone therapy. There are of course other variants luckily for you to start. Zoladex is agonist variant of HT and perhaps they could have you test a antagonist variant like Firmagon (injection) or Orgovyx (daily pill).

Just curious, I suppose they had you on Bicalutamide (Casodex) in time (x weeks) before you had your first Zoladex correct?

Best wishes - Ulf

Tonyberk 2 months ago in reply to Ulfhbg

Yes - I was on Bicalutamide for about 9 months prior to Zoladex, with no serious reactions.

Ulfhbg 2 months ago in reply to Ulfhbg

Hi !

Good and just checking. Anyway, lots of alternatives instead of Zoladex and if I understand you correctly those serious side effects is gone / has diminished and you still have some time left before you need a refill of some sort.

My personal experience is with Firmagon (monthly injection) and currently Orgovyx (daily pill) and they are both HT antagonist both but do the same as Zoladex (which is a agonist); suppressing the production of Testosterone.

Best wishes - Ulf

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