Has anyone had surgery for a T4 lesion spread outside the prostate to nodes and near rectum but not involving and no bone spread . I have had chemotherapy initially with HT injections & psa dropped to 5 from 50.3 . Pet scan shows no nodes and reduction in size of prostate but still spread is there outside prostate but less . All evidence is for RT but one surgeon says we can do prostate removal and then RT after to reduce tumor bulk . There is only observation studies for this but not evidence based studies like RT . I understand his argument. Anyone in similar situation?? Had surgery for a T4 lesion . I know until T3 it can be done . But anyone brave enough to have it done at T4 ? Please let me know. Would be great to have some advise
Hi Mcjc, all the men I know with T4 haven’t had surgery. Hopefully others will answer too. I think having the cancer near the rectum would make radiotherapy on its own very challenging due to the potential damage it would cause. Best wishes,
Ido4
Hi M
Just my opinion but I think that the last chance for having surgery is a T3 and even then can be challenging as T3 indicates broken through the prostate gland.
I see that the surgeon is suggesting surgery followed by Radiotherapy but this would potentially give you more side effects.
What is your preference, would u consider just HT and RT?
Hopefully others will give their opinions.
Best wishes
Steve
Hi
this is the dilemma from the start
a surgeons argument always is reduce tumor bulk and the psa reduces and if you give RT and there is a recurrence then doing surgery as a salvage is very difficult as the tissues will be like rock due to RT . And they do do it in centres like Germany etc and there is observation studies which are good for T4 lesions and he says the only reason it was not included as an option here in uk in the trial was lack of funding
the oncologist argument is you have to have RT to the prostate anyway after surgery . Surgery will not give full clearance so why don’t you go for something which will give curative treatment in one shot RT and is evidence based as in the trial proven to be of benefit ( surgeons say that’s Bcos they have funding in that arm of the stampede trial whereas they did not !) and RT also has side effects as lesion near rectum
so I think end of the day each has its pros & cons and I have to weigh risk benefits ratio . I will probably go for majority who say RT is better . Second option . Let’s c what other friends on forum say . Keep it coming
In a way I see where the surgeon is coming from, give it two best shots to clear it but u r going to have to go through all these treatments which can be very draining. Also don't forget side effects.
Radiotherapy is a lot simpler and using HT before to reduce tumour size making it easier to zap .
If it was me, just my opinion, I would go for the latter.
Steve
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