My Dad’s Advance Prostate Cancer.

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Hi new here happy to have found an informed and helpful community in relation to this terrible disease. My Dad (82) has today unfortunately been asked to make a decision on his next course of treatment for his apc. To date he has tried zoladex, radiation therapy, and most recently abiraterone. His choice now is to choose between chemo -  doccetaxal every 21 days in conjunction with Prednisolone or to potentially take part in a clinical trial of either just 160mg of enzulatamide or group b enzulatamide 160mg plus Lu-PSMA. I believe it might be customary to try enzulatamide if arbiraterone is not working so I’d suspect he’d be better to try that before chemo? If that is at least possibly true should he participate in the trial with the 50% chance of simultaneously trying  Lu-PSMA? Is much known about the latter. don’t want him to be a guinea pig near the end of his life. Any informed assistance in making this decision would be greatly appreciated. Need to confirm with his oncologist in 4 days time!

  • There are no certainties in life, alas, but I'd go for the trial. There's a fair bit of research now on Lu-PSMA, and he may get some benefit. Either way, he'll get close monitoring, and if needs be, he will probably still get a chance on another option.

    I understand your worries about the 'guinea pig' thing, but there are positive signs about new treatments, and sometimes the (small) risks are preferable to the alternatives. the real tragedy with PCa is that most current treatments are pretty awful; Lu-PSMA's 'selling point' is that it offers a chance of a targeted treatment with fewer side effects.

    - - -

    Heinous

    If I can't beat this, I'm going for the draw.

    Meanwhile, my priority is to live while I have the option.

  • Thank you so much for your incredibly informative response, you can’t believe how greatly appreciative my family and I are to you for your considerate input Heinous, bless you.