Caelyx - Ovarian cancer

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Hi, my cancer (stage 3c now 4). was unfortunately discovered late after many trips to GP. I had a great surgeon in Southampton who truly saved my life.  After Debulking and many different types of chemo my first Caelyx infusion was 4 wks ago.  
My question is if there is no decrease in CA 125 figures just prior to the 2 infusion does this signal that drug is not working.  If anyone has experience of this drug and its outcome please advise as I have no idea where I go from here.