Understanding histopathology report

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Hi,

I was wondering if anyone might be able to help me understand this histopathology report please?

One nurse told me that it suggests a high grade tumour (in line with the biopsy result) and especially because it grew 8cm in 12 weeks, whilst another CNS says it's a grade 1 tumour. I am trying to get an appointment with my gynae-oncologist but he is currently away so any advice I can get in the meantime, would be much appreciated.

"Large smooth surfaced lobulated tumour....no evidence of exposure at receipt....multicystic neoplasm with cavities of varied sizes filled with mucin or blood; no definite tumour necrosis is identified. Sections show ovary with extensive infiltration.... Tumour cells are of a large size; they contain irregular nuclei with prominent nucleoli and moderately abundant cytoplasm; they form glands, cribriform nests or tubes. No Necrosis is identified. No squamous differentiation is noted. Tumour cells are positive with cytokeratin 7 and ER markers. There are also quite numerous clusters of Lydia cells which are faintly stained by inhibit marker. They could represent reactive hyperplasia; however an associated component of sex cord tumour remains a possibility."

Thank you.

  • Hi  

    I know we have spoken before so I’m just replying so you know your post has been read. 

    All of us within groups are either cancer patients or caring for those with cancer so are not medical professionals. With this in mind, we can speak about our own experiences but we can’t attempt to interpret histology reports as we don’t have the appropriate knowledge. 

    I see you have asked questions in the “ask a nurse” section before, so the best thing to do is pose your question there and they may be able to help in general terms without knowing your full medical history. Better still would be to have the detail explained to you by your consultant to make sure you understand everything fully.

    Sarah xx


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