Clinical trials

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Hi, my hubby diagnosed with mesothelioma in Feb. Such a shock as they gave 1 to 2 years without treatment as he was alright at T3N1M0. Thankfully he had been accepted on a clinical trial in Manchester. Like so many of the comments I'm putting a brave face on but crumbling inside. From 1 scan to the next it had doubled so I'm now worried. Although he seems to be staying positive he appears very tired all the time. Has anyone had any success with a trial when all else wouldn't work? Any advice would be appreciated.