Dabrafenib and Trametinib

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I’ve only been taking these for a few weeks so far and have been a bit up and down, mostly with tiredness, aches and occasional nausea, which I expected as I know it’ll be good days and bad.

One thing that I didn’t expect was to develop large red blotches on my arms, upper torso and face. These were a bit nippy and sore, now some of them have died down but have left what looks like mild bruising.

They are roughly about the size of a fingerprint and seem to flare up then fade.

i know the pills can cause some weird and wonderful side effects and wondered if anyone else had experienced this?

  • Hi  

    I haven't had the treatment you're on so don't have any experiences with sore, large, red blotches on my body. My first thought is, have you reported these side effects to your treatment team?

    Responding to your post will 'bump' it back to the top of the discussion list, and hopefully members who've had these combination of drugs will pop on to share their experiences with you.

     While you're waiting for replies, it would be great if you could put something about your diagnosis and treatment to date into your profile as it really helps others when replying to you and also when looking for someone on a similar pathway. It also means that you don't have to keep repeating yourself. To do this click on your username and then select 'Profile'. You can amend it at any time and if you're not sure what to write you can take a look at mine by clicking on my username.

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  • Hi after 6 weeks of taking these dab and tram I had fevers cough then spots on forehead which turned into acne rash and few spots on arms and back. I had to stop them for 3 weeks then I restarted then a week before finishing the 4th cycle fevers and cough came back then liver function test was to high had grade 3 toxins so stopped taking for now. Now I've been diagnosed with thyroid papillary carcinoma cancer now waiting on surgery. Might be starting back on dab and tram when I have recovered from the thyroid. Only knew about the thyroid because of pet scan to check melanoma had not spread.

  • Hi, I have just started dab tran & noticing similar things on my skin. Did you ever find out if it was a side effect? How are you doing now on the tablets, hope it's going well for you?

  • Hi im not on dab and tram I only done 4 months I'm  on sullviance scans and skin checks now. What stage is your melanoma. I had 2 toxic side affects and found thyroid cancer. Too long gap to go back on them and I've been told its only 10 percent chance of coming back  mine is stage 3a

  • Also I have had surgery for the thyroid cancer and it was successful just 9n levothyroxine for rest of life and on calcium tablets