Braftovi and Mektovi, side effects and timings of tablets experience please.

Former Member
Former Member
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Hi I’m looking for some experience of of these tablets and the timings of how you took it and what made you choose that way round and what side effects if any you’ve had. I know every one is different and that we can choose our own times just looking for a bit of experience before I start these tablets.

https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/encorafenib-and-binimetinib

I have the patient treatment booklets and diary and I’ve previously had Dabrafenib and where you have the 12 hrs apart thing but you also have the other timings when you can’t eat, so really pleased no restrictions with when to eat but hadn’t appreciated there were so many tablets.

Im thinking along the lines of 3 mektovi in the am and then the other 3 with the 6 Bravtovi in the pm. I’m thinking 8 pm for the bulk of the tablets so that I’ve eaten and if the bulk of the tablets make me sleepy this might be the best way to cope. I’m already on antisickness tablets since my surgery  and this is making me tired for a few hours after taking. I’ve heard some people have taken the bulk in the am to help with sickness so I was looking for anyone’s real life experience please.

Thank you for any comments

  • I have been taking Mektovi and Braftovi since last March.  Almost 1 year now.  I take half dose due to high fevers at the beginning.  I have remained stable now.  Some fatigue and joint aches.  I was told to have dosing 12 hours apart - I take the 2 tabs of Mektovi at 9 a.m. ( I always set an alarm) and 1 mektovi plus 3 braftovi at 9 p.m.  I do take 1 compazine in the evening.  I was told it is easier to take the "larger" dose in the evening to sleep through those side effects.  

    The joint issues started a couple months after taking and I keep trying physical therapy etc.  So far trying to avoid steroids.  They say it is hard to pin point the cause.  My stiffness and aches increase with physical exercise.

    Hope these meds keep working for many of us - with minimal side effects!