Pemetrexed Side Effects

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Hello, 

My other half is on maintenance Pemetrexed every 3 weeks and the past couple of cycles he's reported a 'cold' feeling in his oesophagus area - no shortness of breath, pain, issues with swallowing/breathing etc. 

Has anyone else every experienced this? We mentioned it at our last oncology appt and the stand in registrar (oncologist on sick) didn't seem too bothered, but with each cycle it seems to be lasting that bit longer.

Thanks