Side effects Regorafenib

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My partner was diagnosed with Primary Liver Cancer after xrays and scans for blood in his pee 3 years ago. That was found to be a water infection. But the scans showed something on the Liver. We were sent to Freeman Hospital in Newcastle and were seen by a Professor Manos. He confirmed that Bob my partner had a Primary liver cancer. He had no symptoms so was lucky that he could have treatments but it was inoperable. He was placed on Sorafenib which did its job for 2.5 year stopped the tumour growing and kept it in place. A routine scan showed a slight increase in size of tumour the oncologist said that we should change treatment for more effectiveness and he is now on Regorafenib. He has the usual side effects extreme fatigue. A year ago before the change in medication he started to suffer with callouses on his feet. With one foot effected more that the other one. Despite going to the chiropodist which he now visit every 3 weeks this is getting progressively worse since the new.medication. it is now becoming extremely painful and effecting his lifestyle. We have tried every cream on the market. We have bought numerous insoles and gel soles all to no benefit. He is now trying a spring loaded walking stick to help walking. This is having a detrimental effect on our positive upbeat attitude.

Has anyone else had this problem and how are you dealing with it.

  • Hi and welcome to the online community

    I'm sorry to read how much discomfort your partner is in from the callouses on his feet.

    I used the group search bar to look for previous posts on this topic but drew a blank I'm afraid. This doesn't necessarily mean that it hasn't happened to others but maybe just that they haven't posted about it.

    This is Macmillan's information on common side effects of using Sorafenib which does have a section on 'changes to hands and feet', although it doesn't mention callouses. This is Cancer Research's information on side effects of using Regorafenib which mentions something called hand-foot syndrome.

    What do his hospital team think is the probable cause? If they haven't been able to help you could post your question in the ask a nurse section of the online community and one of the specialist nurses will aim to reply within three working days.

    It would be great if you could pop something about your partner's journey with liver cancer into your profile as it really helps others when answering or looking for someone with a similar diagnosis. It also means that you don't have to keep repeating yourself. To do this click on your username and then select 'Profile'. You can amend it at any time and if you're not sure what to write you can take a look at mine by clicking on my username.

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