My husband was diagnosed with GBM in June 2018 rolling over 6 months of symptoms. The tumour was inoperable, but he had the radiotherapy and chemo combo followed by 6 months on TMZ - the only side effect he experienced was a tiredness around the second week of each cycle. After the 6 months, he was monitored 3 monthly, all scans favourable showing slight improvement each time. In April this year his usual scan showed changes and he was prescribed another course of TMZ. Due to COVID, I could not attend this appointment with him, so I’m not really sure what he was told. After his second cycle of tmz he experienced Loose bowel movements and urgency for a few weeks, culminating in an episode of chills and flushes, extreme nausea and generally feeling rubbish. He was checked out at a&e, bloods, electrolytes etc good. The nausea continued when he got home, he was prescribed 4mg of ondansetron which sorted him right out. He started his third cycle on Thursday, no ill effects until today. Everything was normal until about 10am when he started bumping into things. I sent him straight to bed and he had a definite left sided weakness in his arm and leg, and he said he felt twitchy. All through this he was conscious, no issues with his speech and his memory was the best it has been weeks. He’s still unsteady on his feet, and even walking to the loo is an issue. He says he is feeling steadier when he is sitting, but still unsteady when walking. I’m wondering if anyone has experienced this kind of thing before, or if it might have been a seizure?
